Molecular IgE sensitization profiles of urban and rural children in South Africa
| Autor: | Jordache Ramjith, Nonhlanhla Lunjani, Wisdom Basera, Ben Gaunt, Irene Mittermann, Carol Hlela, Avumile Mankahla, Michael Levin, Heidi E. Facey‐Thomas, Sabine Flicker, Maresa Botha, Rudolf Valenta, Pia Gattinger, Claudia L. Gray, Jon Genuneit, Sheron Dzoro |
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| Rok vydání: | 2020 |
| Předmět: |
Allergy
Immunology Immunoglobulin E medicine.disease_cause Dermatitis Atopic Mice South Africa 03 medical and health sciences 0302 clinical medicine Allergen Animals Humans Immunology and Allergy Medicine 030212 general & internal medicine Child Ige sensitization Sensitization House dust mite biology business.industry Atopic dermatitis Allergens biology.organism_classification medicine.disease Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] medicine.anatomical_structure 030228 respiratory system Pediatrics Perinatology and Child Health biology.protein Rural area business Food Hypersensitivity |
| Zdroj: | Pediatric Allergy and Immunology, 32, 2, pp. 234-241 Pediatric Allergy and Immunology, 32, 234-241 |
| ISSN: | 1399-3038 0905-6157 |
| Popis: | Item does not contain fulltext BACKGROUND: Allergens can act as disease-triggering factors in atopic dermatitis (AD) patients. The aim of the study was to elucidate the molecular IgE sensitization profile in children with and without AD living in urban and rural areas of South Africa. METHODS: Specific IgE reactivity was assessed in 166 Black South African children aged 9-38 months using a comprehensive panel of microarrayed allergens. According to clinical characterization children fell in four groups, urban AD cases (n = 32), urban controls (non-AD, n = 40), rural cases (n = 49) and rural controls (non-AD, n = 45). RESULTS: IgE reactivity to at least one of the allergens was detected in 94% of urban and 86% of rural AD children. House dust mite (HDM; 81% urban, 74% rural AD) and animal-derived allergens (50% urban, 31% rural AD) were the most frequently recognized respiratory allergens, whereas IgE to pollen allergens was almost absent. Urban AD children showed significantly higher frequency of IgE reactivity (50%) to mouse lipocalin, Mus m 1, than rural AD children (12%). The most frequently recognized food allergens were from egg (63% urban, 43% rural AD), peanut (31% vs 41%), and soybean (22% vs 27%), whereas milk sensitization was rare. α-gal-specific IgE almost exclusively occurred in rural children (AD: 14%, non-AD: 49%). CONCLUSION: Molecular allergy diagnosis detects frequent IgE sensitization to HDM, animal but not pollen allergens and to egg, peanut, and soy, but not milk allergens in African AD children. Urban AD children reacted more often to Mus m 1, whereas α-gal sensitization is more common in rural children likely due to parasite exposure. |
| Databáze: | OpenAIRE |
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