The role of 5-HTTLPR in autism spectrum disorder: New evidence and a meta-analysis of this polymorphism in Latin American population with psychiatric disorders

Autor: María Claudia Lattig, L. Galeano, A. Lopez, D. L. Nuñez-Rios, R. Chaskel
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Pervasive Developmental Disorders
Latin Americans
Heredity
Bipolar Disorder
Autism Spectrum Disorder
Social Sciences
Biochemistry
Severity of Illness Index
0302 clinical medicine
Mathematical and Statistical Techniques
Gene Frequency
Polymorphism (computer science)
Genotype
Medicine and Health Sciences
Psychology
Ethnicities
Serotonin Plasma Membrane Transport Proteins
education.field_of_study
Multidisciplinary
Depression
Statistics
Neurochemistry
Neurotransmitters
Metaanalysis
Population groupings
Genetic Mapping
Autism spectrum disorder
Meta-analysis
Physical Sciences
Medicine
Research Article
Biogenic Amines
Serotonin
Science
Population
Variant Genotypes
Biology
Research and Analysis Methods
Polymorphism
Single Nucleotide
White People
03 medical and health sciences
Asian People
mental disorders
Mental Health and Psychiatry
medicine
Genetics
Humans
Allele
Statistical Methods
education
Alleles
Mood Disorders
Biology and Life Sciences
Latin American people
medicine.disease
030227 psychiatry
Latin America
Genetic Loci
5-HTTLPR
Developmental Psychology
People and places
030217 neurology & neurosurgery
Mathematics
Demography
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0235512 (2020)
ISSN: 1932-6203
Popis: The autism spectrum disorder (ASD) is a complex disorder encompassing a broad phenotypic and genotypic variability. The short (S)/long (L) 5-HTTLPR polymorphism has a functional role in the regulation of extracellular serotonin levels and both alleles have been associated to ASD. Most studies including European, American, and Asian populations have suggested an ethnical heterogeneity of this polymorphism; however, the short/long frequencies from Latin American population have been under-studied in recent meta-analysis. Here, we evaluated the 5-HTTLPR polymorphism in Colombian individuals with idiopathic ASD and reported a non-preferential S or L transmission and a non-association with ASD risk or symptom severity. Moreover, to recognize the allelic frequencies of an under-represented population we also recovered genetic studies from Latin American individuals and compared these frequencies with frequencies from other ethnicities. Results from meta-analysis suggest that short/long frequencies in Latin American are similar to those reported in Caucasian population but different to African and Asian regions.
Databáze: OpenAIRE
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