Human Colonization with Extended-Spectrum Beta-Lactamase-Producing E. coli in Relation to Animal and Environmental Exposures in Bangladesh: An Observational One Health Study
| Autor: | Mahdia Rahman, Leanne Unicomb, Mohammed Badrul Amin, Mohammad Aminul Islam, T.I.M. Amin Uddin Mozmader, Zahid Hayat Mahmud, Muhammad Asaduzzaman, Md. Rayhanul Islam, Emily K. Rousham, Muhammed Iqbal Hossain |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Potential risk
business.industry Transmission (medicine) animal diseases Health Toxicology and Mutagenesis medicine.medical_treatment Public Health Environmental and Occupational Health 010501 environmental sciences Biology 01 natural sciences 03 medical and health sciences 0302 clinical medicine One Health Human exposure Environmental health Beta-lactamase medicine Livestock Colonization Observational study 030212 general & internal medicine business 0105 earth and related environmental sciences |
| Zdroj: | Environmental Health Perspectives. 129 |
| ISSN: | 1552-9924 0091-6765 |
| DOI: | 10.1289/ehp7670 |
| Popis: | Background: Human exposure to intensively farmed livestock is a potential risk for transmission of antibiotic-resistant bacteria (ARB) but few studies have assessed the relative role of animal vs. environmental sources of ARB in low-resource community settings. Objectives: We conducted an observational study to compare ARB colonization and antibiotic-resistant gene prevalence and abundance in humans with high or low exposure to poultry in rural households, commercial poultry farms, and urban markets in Bangladesh. Methods: Extended-spectrum β-lactamase (ESBL)-producing and carbapenem-resistant E. coli were quantified in feces from adults with high or low poultry exposure (n=100, respectively), poultry (n=200), drinking water (n=120), and wastewater (n=120) from 40 rural households, 40 poultry farms, and 40 urban markets. Results: ESBL-producing E. coli (ESBL-EC) prevalence was 67.5% (95% CI: 61.0, 74.0) in samples from adults, 68.0% (95% CI: 61.5, 74.5) in samples from poultry, and 92.5% (95% CI: 87.7, 97.3) in wastewater samples. Carbapenem-resistant E. coli prevalence was high in market wastewaters [30% (95% CI: 15.0, 45.0)] but low in humans (1%) and poultry (1%). Human, poultry, and wastewater isolates shared common resistance genes: blaCTX-M-1, qnr, and blaTEM. Human colonization was not significantly associated with exposure to poultry or setting (rural, farm, or market). Ninety-five percent of commercial poultry farms routinely administered antibiotics. Susceptibility tests were significantly different in household vs. farm and market poultry isolates for four of seven antibiotic classes. In human isolates, there were no differences except aminoglycoside resistance (16.4% high vs. 4.4% low exposure, p=0.02). Urban market wastewaters and poultry samples had significantly higher concentrations of ESBL-EC (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|