Unsuspected Caffeine Toxicity Complicating Theophylline Therapy
| Autor: | R.D. Levy, S.A. Iversen, T.E.B. Leakey, P.G. Murphy, A. Rydlewski, D. Gertner |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Tachycardia Alcoholic liver disease Health Toxicology and Mutagenesis Pharmacology Toxicology Airflow obstruction 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Theophylline Caffeine medicine Humans 030212 general & internal medicine Bronchitis Liver Diseases Alcoholic business.industry Middle Aged medicine.disease chemistry Heart failure Toxicity medicine.symptom business Half-Life medicine.drug |
| Zdroj: | Human Toxicology. 3:509-512 |
| ISSN: | 0144-5952 |
| DOI: | 10.1177/096032718400300606 |
| Popis: | 1 A 58-year-old man with a history of alcoholic liver disease and chronic airflow obstruction presented with heart failure and acute bronchitis. 2 Plasma methylxanthines were estimated as a guide to further theophylline therapy and serious caffeine accumulation was noted in the presence of a subtherapeutic concentration of theophylline. 3 After 3 weeks on a caffeine-free diet theophylline and caffeine challenge tests were performed which demonstrated the ease with which caffeine could accumulate. 4 The importance of caffeine accumulation during theophylline therapy is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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