Immunoregulatory role of lactoferrin-lipopolysaccharide interactions
| Autor: | Daniela Latorre, Sandra Gessani, Piera Valenti, Patrizia Puddu |
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| Rok vydání: | 2010 |
| Předmět: |
Lipopolysaccharides
Lipopolysaccharide biology Lactoferrin Inflammatory response Metals and Alloys Inflammation medicine.disease General Biochemistry Genetics and Molecular Biology Biomaterials Sepsis Exocrine secretion chemistry.chemical_compound Immune system chemistry Immunology medicine biology.protein Animals Humans medicine.symptom General Agricultural and Biological Sciences immune response inflammation lactoferrin lipopolysaccharide Immune activation |
| Zdroj: | BioMetals. 23:387-397 |
| ISSN: | 1572-8773 0966-0844 |
| Popis: | Lactoferrin (Lf) is a mammalian exclusive protein widely distributed in milk and exocrine secretions exhibiting multifunctional properties. Many of the proven or proposed functions of Lf, apart from its iron binding activity, depend on its capacity to bind to other macromolecules. Lf can bind and sequester lipopolysaccharide (LPS), thus preventing pro-inflammatory pathway activation, sepsis and tissue damage. However, the interplay between Lf and LPS is complex, and may result in different outcomes, including both suppression of the inflammatory response and immune activation. These findings are critically relevant in the development of Lf-based therapeutic interventions in humans. Understanding the molecular basis and functional consequences of Lf-LPS interaction will provide insights for determining its role in health and disease. |
| Databáze: | OpenAIRE |
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