A theoretical framework for determining cerebral vascular function and heterogeneity from dynamic susceptibility contrast MRI
| Autor: | Ingrid Digernes, Atle Bjørnerud, Einar O. Vik-Mo, Kyrre E. Emblem, Fredric A A Courivaud, Torstein R. Meling, Svein Are Sirirud Vatnehol, Grethe Løvland |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
vessel architectural imaging
Tumour heterogeneity DSC-MRI Cerebrovascular Circulation/physiology Contrast Media Transit time computer.software_genre Models Biological Magnetic Resonance Imaging/methods 030218 nuclear medicine & medical imaging Brain/blood supply/diagnostic imaging/metabolism 03 medical and health sciences 0302 clinical medicine Models Voxel glioma medicine Humans Vascular tissue Capillaries/diagnostic imaging Physics medicine.diagnostic_test vascular modelling Brain Magnetic resonance imaging Anatomy Blood flow Original Articles Biological Oxygen/metabolism Magnetic Resonance Imaging ddc:616.8 Capillaries Oxygen Neurology Cerebrovascular Circulation Neurology (clinical) tumour heterogeneity Cardiology and Cardiovascular Medicine Vascular function computer Monte Carlo Method 030217 neurology & neurosurgery Dynamic susceptibility Biomedical engineering |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism Journal of Cerebral Blood Flow and Metabolism, Vol. 37, No 6 (2017) pp. 2237-2248 |
| ISSN: | 1559-7016 0271-678X |
| Popis: | Mapping the complex heterogeneity of vascular tissue in the brain is important for understanding cerebrovascular disease. In this translational study, we build on previous work using vessel architectural imaging (VAI) and present a theoretical framework for determining cerebral vascular function and heterogeneity from dynamic susceptibility contrast magnetic resonance imaging (MRI). Our tissue model covers realistic structural architectures for vessel branching and orientations, as well as a range of hemodynamic scenarios for blood flow, capillary transit times and oxygenation. In a typical image voxel, our findings show that the apparent MRI relaxation rates are independent of the mean vessel orientation and that the vortex area, a VAI-based parameter, is determined by the relative oxygen saturation level and the vessel branching of the tissue. Finally, in both simulated and patient data, we show that the relative distributions of the vortex area parameter as a function of capillary transit times show unique characteristics in normal-appearing white and gray matter tissue, whereas tumour-voxels in comparison display a heterogeneous distribution. Collectively, our study presents a comprehensive framework that may serve as a roadmap for in vivo and per-voxel determination of vascular status and heterogeneity in cerebral tissue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|