Involvement of Different Types of Dopamine Receptors in the Formation of Latent Inhibition of a Conditioned Passive Avoidance Reaction in Rats
| Autor: | N. I. Dubrovina, N. V. Kostyunina, L. V. Loskutova |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Agonist Quinpirole medicine.drug_class Pharmacology Developmental psychology Latent inhibition Dopamine receptor D1 Avoidance Learning Haloperidol medicine Animals Rats Wistar Receptor Receptors Dopamine D2 Chemistry Receptors Dopamine D1 General Neuroscience Dopaminergic Rats Dopamine D2 Receptor Antagonists Dopamine receptor Conditioning Operant 2 3 4 5-Tetrahydro-7 8-dihydroxy-1-phenyl-1H-3-benzazepine medicine.drug |
| Zdroj: | Neuroscience and Behavioral Physiology. 40:483-487 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-010-9285-5 |
| Popis: | The effects of systemic injections of dopaminergic agents on normal and weak latent inhibition of a conditioned passive avoidance reaction were studied in rats. Formation of normal latent inhibition was induced using 20 pre-exposures to a contextual conditioned stimulus prior to training. Weak latent inhibition was modeled using 10 pre-exposures. The effects of the D(2)/D(3) receptor agonist quinpirole (1 mg/kg) and the D(1) receptor agonist SKF 38393 (1 mg/kg) separately and in combination with haloperidol (0.5 mg/kg) were tested. Quinpirole induced the expression of normal latent inhibition but had no effect on weak latent inhibition. Activation of D(1) receptors with SKF 38393 had no effect on the formation of latent inhibition regardless of the number of pre-exposures. Haloperidol significantly strengthened weak latent inhibition but impaired normal latent inhibition. Administration of haloperidol in combination with SKF 38393 prevented this impairment. These results suggest that while D(1) receptors have no influence as an independent substrate on the formation of latent inhibition, activation of these receptors is required for the complete manifestation of D(2)-mediated modulation of this process. |
| Databáze: | OpenAIRE |
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