Functional MRI Shows Altered Deactivation and a Corresponding Decrease in Functional Connectivity of the Default Mode Network in Patients with Gliomas
| Autor: | Y.M. Maniar, Mehrnaz Jenabi, Kyung K. Peck, Madeleine Gene, Andrei I. Holodny |
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| Rok vydání: | 2021 |
| Předmět: |
Gyrus Cinguli
behavioral disciplines and activities 030218 nuclear medicine & medical imaging Task (project management) Correlation 03 medical and health sciences 0302 clinical medicine Text mining Cortex (anatomy) medicine Humans Radiology Nuclear Medicine and imaging In patient Default mode network Brain Mapping Functional business.industry Functional connectivity Brain Default Mode Network Glioma Magnetic Resonance Imaging medicine.anatomical_structure Posterior cingulate Neurology (clinical) business Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | AJNR Am J Neuroradiol |
| ISSN: | 1936-959X 0195-6108 |
| DOI: | 10.3174/ajnr.a7138 |
| Popis: | BACKGROUND AND PURPOSE: The default mode network normally decreases in activity during externally directed tasks. Although default mode network connectivity is disrupted in numerous brain pathologies, default mode network deactivation has not been studied in patients with brain tumors. We investigated default mode network deactivation with language task–based fMRI by measuring the anticorrelation of a critical default mode network node, the posterior cingulate cortex, in patients with gliomas and controls; furthermore, we examined default mode network functional connectivity in these patients with task-based and resting-state fMRI. MATERIALS AND METHODS: In 10 healthy controls and 30 patients with gliomas, the posterior cingulate cortex was identified on task-based fMRI and was used as an ROI to create connectivity maps from task-based and resting-state fMRI data. We compared the average correlation in each default mode network region between patients and controls for each correlation map and stratified patients by tumor location, hemisphere, and grade. RESULTS: Patients with gliomas (P = .001) and, in particular, patients with tumors near the posterior default mode network (P < .001) showed less posterior cingulate cortex anticorrelation in task-based fMRI than controls. Patients with both left- and right-hemisphere tumors, as well as those with grade IV tumors, showed significantly lower posterior cingulate cortex anticorrelation than controls (P = .02, .03, and |
| Databáze: | OpenAIRE |
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