Cytoreductive Nephrectomy in Elderly Patients with Metastatic Renal Cell Carcinoma in the Targeted Therapy Era
| Autor: | Dipesh Uprety, Amir Bista, Yazhini Vallatharasu, David E. Marinier, Angela L. Smith |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Multivariate analysis medicine.medical_treatment Kaplan-Meier Estimate Nephrectomy Targeted therapy 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma Internal medicine Statistical significance medicine Humans 030212 general & internal medicine Cytoreductive nephrectomy Carcinoma Renal Cell Aged Proportional Hazards Models Retrospective Studies Aged 80 and over business.industry Proportional hazards model General Medicine medicine.disease Kidney Neoplasms Log-rank test Survival benefit Case-Control Studies Female business 030217 neurology & neurosurgery SEER Program |
| Zdroj: | Anticancer research. 38(5) |
| ISSN: | 1791-7530 |
| Popis: | BACKGROUND/AIM The role of cytoreductive nephrectomy (CN) for metastatic renal cell cancer (mRCC) is not clearly understood after the approval of targeted therapies, particularly in the elderly population. The aim of this study was to compare survivals between patients who did and did not receive CN. PATIENTS AND METHODS The SEER-18 database was utilized in order to identify elderly patients with mRCC to compare overall survival (OS) and cancer-specific survival (CSS) between patients who did or did not receive CN between February 2006 and 2012. Kaplan-Meier curve and log rank test were used to compare OS and CSS between these two arms. Cox proportional hazard model was used for multivariate analysis and statistical significance was defined as p≤0.05. RESULTS There was a significant survival benefit for those who received CN compared to those who did not receive CN (median OS: 18 months vs. 4 months, p |
| Databáze: | OpenAIRE |
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