Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study: newborn anthropometrics and childhood glucose metabolism
| Autor: | Lynn P. Lowe, Alan R. Dyer, Denise M. Scholtens, Jami L. Josefson, Boyd E. Metzger, William L. Lowe, Monica E. Bianco, Patrick M. Catalano, Alan Kuang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose Male 0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism Carbohydrate metabolism Risk Assessment Article Young Adult 03 medical and health sciences 0302 clinical medicine Insulin resistance Pregnancy Risk Factors Diabetes mellitus Internal Medicine medicine Birth Weight Humans Prospective Studies Family history Child education Adiposity education.field_of_study C-Peptide business.industry Obstetrics Age Factors Infant Newborn Anthropometry Fetal Blood medicine.disease Skinfold Thickness 030104 developmental biology Hyperglycemia Prenatal Exposure Delayed Effects Cohort Female Insulin Resistance business Biomarkers Follow-Up Studies |
| Zdroj: | Diabetologia |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/s00125-020-05331-0 |
| Popis: | AIMS/HYPOTHESIS: We aimed to examine associations of newborn anthropometric measures with childhood glucose metabolism with the hypothesis that greater newborn birthweight, adiposity and cord C-peptide are associated with higher childhood glucose levels and lower insulin sensitivity. METHODS: Data from the international, multi-ethnic, population-based Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and the HAPO Follow-Up Study were used. The analytic cohort included 4155 children (mean age [SD], 11.4 [1.2] years; 51.0% male). Multiple linear regression was used to examine associations of primary predictors, birthweight, newborn sum of skinfolds (SSF) and cord C-peptide, from HAPO with continuous child glucose outcomes from the HAPO Follow-Up Study. RESULTS: In an initial model that included family history of diabetes and maternal BMI during pregnancy, birthweight and SSF demonstrated a significant, inverse association with 30 min and 1 h plasma glucose levels. In the primary model, which included further adjustment for maternal sum of glucose z scores from an oral glucose tolerance test during pregnancy, the associations were strengthened, and birthweight and SSF were inversely associated with fasting, 30 min, 1 h and 2 h plasma glucose levels. Birthweight and SSF were also associated with higher insulin sensitivity (Matsuda index) (β = 1.388; 95% CI 0.870, 1.906; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink