Insulin-Like Growth Factor-1 Lowers Protein Oxidation in Patients with Thermal Injury
| Autor: | Gretchen Carrougher, William F. McManus, Loring W. Rue, William G. Cioffi, Dennis C. Gore, Hans Peter Guler, Basil A. Pruitt |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Carbohydrate metabolism Protein oxidation Insulin-like growth factor Internal medicine Humans Medicine Insulin-Like Growth Factor I Infusions Intravenous Thermal injury business.industry Catabolism Insulin Proteins Middle Aged Protein catabolism Glucose Endocrinology Hypermetabolism Surgery Burns Energy Metabolism business Oxidation-Reduction Research Article |
| Zdroj: | Annals of Surgery. 220:310-319 |
| ISSN: | 0003-4932 |
| DOI: | 10.1097/00000658-199409000-00007 |
| Popis: | OBJECTIVE: The effect of insulin-like growth factor-1 (IGF-1) on energy expenditure and protein and glucose metabolism in a group of patients with thermal injury was determined. SUMMARY BACKGROUND DATA: Accelerated protein catabolism is a constant feature of the hypermetabolic response to thermal injury. Insulin-like growth factor-1 has been reported to minimize protein catabolism and normalize energy expenditure in animal models of thermal injury. METHODS: To determine the efficacy of IGF-1 in human burn patients, resting energy expenditure (metabolic cart), whole body protein kinetics (N15 Lysine), and glucose disposal (glucose tolerance test) were assessed in eight burn patients before and after a 3-day infusion of IGF-1 (20 micrograms/kg/hr). All patients were fluid-resuscitated uneventfully and were without obvious infection at the time of study. Enteral nutrition was administered at a constant rate before and during the IGF-1 infusion. RESULTS: Resting energy expenditure was not altered by IGF-1 (40.3 +/- 2.2 vs. 39.1 +/- 2.3 kcal/kg/day). However, glucose uptake was promoted, and protein oxidation decreased significantly (0.118 +/- 0.029 vs. 0.087 +/- 0.021 g/kg/d, p < 0.05) by IGF-1. In addition, insulin secretion, in response to a glucose challenge, was blunted. CONCLUSIONS: Insulin-like growth factor-1 therapy has a beneficial effect in preserving lean body mass during severe stress conditions by minimizing the flux of amino acids toward oxidation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|