The furosemide stress test: current use and future potential

Autor: Lakhmir S. Chawla, Blaithin A. McMahon
Jazyk: angličtina
Rok vydání: 2021
Předmět:
medicine.medical_specialty
medicine.drug_class
Critical Illness
medicine.medical_treatment
030232 urology & nephrology
Volume overload
Review
Nephron
030204 cardiovascular system & hematology
Critical Care and Intensive Care Medicine
urologic and male genital diseases
Electrolytes
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Renal replacement therapy
furosemide
Diuretics
Intensive care medicine
Randomized Controlled Trials as Topic
business.industry
urogenital system
Acute kidney injury
Furosemide
risk assessment
General Medicine
Loop diuretic
medicine.disease
Pulmonary edema
female genital diseases and pregnancy complications
Diseases of the genitourinary system. Urology
Review article
medicine.anatomical_structure
acute kidney injury
Nephrology
State-of-the-Art Review
Exercise Test
stress test
RC870-923
business
renal replacement therapy
medicine.drug
Zdroj: Renal Failure, Vol 43, Iss 1, Pp 830-839 (2021)
Renal Failure
article-version (VoR) Version of Record
ISSN: 1525-6049
Popis: Loop diuretics are among the most widely used drugs worldwide and are commonly employed in the management of complications associated with acute kidney injury (AKI), namely volume overload and electrolyte management. The use of loop diuretics in critically ill patients with AKI is paramount to preventing or treating pulmonary edema. The naturetic response to a loop diuretic is based on its unique renal pharmacology. Our review article summarizes the pharmacology of furosemide in the intact nephron and discusses how this response might be altered by the presence of AKI. We discuss the increasing body of literature on the latest clinical utility of furosemide namely, it’s challenge test, known as the furosemide stress test which has highlighted a new and novel role for furosemide over the past number of years. This test assists with the identification of AKI subjects at higher risk of AKI progression and the need for renal replacement therapy. The stress test can also predict cessation of continuous renal replacement therapy in patients with established AKI. On the basis of the evidence presented in this review, we propose future potential studies of furosemide in AKI.
Databáze: OpenAIRE
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