Association of a CA repeat polymorphism upstream of the Fas ligand gene with multiple sclerosis
| Autor: | Marı́a J Fernández-Pérez, Francisca Solano, Miguel Lucas, Guillermo Izquierdo, Marı́a D Zayas |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Fas Ligand Protein Multiple Sclerosis Genotype Immunology Apoptosis Biology Fas ligand Polymorphism (computer science) HLA-DQ Antigens Internal medicine medicine HLA-DQ beta-Chains Humans Immunology and Allergy Allele Family history HLA-DRB1 Alleles Repetitive Sequences Nucleic Acid Membrane Glycoproteins Polymorphism Genetic Multiple sclerosis Haplotype HLA-DR Antigens Odds ratio medicine.disease Molecular biology Phenotype Endocrinology Neurology Neurology (clinical) HLA-DRB1 Chains |
| Zdroj: | Journal of Neuroimmunology. 116:238-241 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/s0165-5728(01)00309-5 |
| Popis: | We have analyzed a CA repeat polymorphism localized 46-kb upstream of the Fas ligand gene in Spanish and American populations that include 139 healthy controls and a cohort of 177 unrelated relapsing and remitting multiple sclerosis (MS) patients. The MS patients consisted of two groups, one with a family history of MS and one without. The frequency of the 13 CA repeats (allele B) was lower (p=0.01) in MS patients than in controls, 0.45 and 0.55 respectively. The odds ratio (BB vs. AB/AA) for MS patients vs. healthy controls was 0.51 (95% CI 0.3–0.9; p=0.01). The odds ratio (BB vs. AB/AA) for MS patients extracted from multiply affected families vs. healthy controls was 0.22 (95% CI 0.07–0.62; p=0.002). The HLA DRB1*1501–DQB1*0602 haplotype is associated with B allele with a relative frequency higher than A allele (0.52 and 0.48 in patients vs. 0.68 and 0.32 in controls). The results suggest that chromosomes with B allele have a genetic background that reduces susceptibility to MS, particularly in the familial forms. |
| Databáze: | OpenAIRE |
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