Analgesia effect of premixed nitrous oxide/oxygen during the rehabilitation after total knee arthroplasty: a study protocol for a randomized controlled trial
| Autor: | Jian-Qiang Yu, Li-Ting Wang, Yu-Xiang Li, Yi-Ling Wang, Qiang Liu, Xiao-Min Chai, Dong-Mei Bao, Kai-Bin Wang, Jun-Jun Zhang, Ning Zhu, Lu-Lu Gao, Ya-Liang Dai, Wen-Qiang Bao, Xue-Sen Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Knee arthritis
Male medicine.medical_specialty China Time Factors Knee Joint medicine.medical_treatment Analgesic Medicine (miscellaneous) law.invention 03 medical and health sciences Study Protocol 0302 clinical medicine Randomized controlled trial Double-Blind Method law medicine Humans Pharmacology (medical) 030212 general & internal medicine Arthroplasty Replacement Knee Aged Pain Measurement Randomized Controlled Trials as Topic Pain Postoperative lcsh:R5-920 Rehabilitation Nitrous oxide business.industry Arthritis Oxygen Inhalation Therapy Analgesics Non-Narcotic Middle Aged medicine.disease Arthralgia Pulmonary embolism Exercise Therapy Treatment Outcome Physical therapy Female Analgesia Range of motion Cancer pain business lcsh:Medicine (General) 030217 neurology & neurosurgery |
| Zdroj: | Trials, Vol 20, Iss 1, Pp 1-8 (2019) Trials |
| ISSN: | 1745-6215 |
| DOI: | 10.1186/s13063-019-3472-7 |
| Popis: | Background The morbidity of knee arthritis is increasing among aged people and total knee arthroplasty has been its mainstream treatment to date. Postoperative rehabilitation is an important part of the procedure. However, the intense pain during the functional exercise involved has always been a challenge for both patients and health care professionals. The aim of this study is to test the analgesic effect of a mixture of nitrous oxide/oxygeb (1:1) inhalation for patients who are doing functional exercise 1 month after total knee arthroplasty. Methods/design This double-blind, randomized, placebo-controlled study will be implemented in the Rehabilitation Department in the General Hospital of Ningxia Medical University. Patients aged between 50 and 75 years who underwent a primary unilateral total knee arthroplasty are eligible for inclusion. The key exclusion criteria include: epilepsy, pulmonary embolism, intestinal obstruction, aerothorax. The treatment group (A) will receive a pre-prepared nitrous oxide/oxygen mixture plus conventional treatment (no analgesics), and the control group (B) will receive oxygen plus conventional treatment (no analgesics). Patients, physicians, therapists, and data collectors are all blind to the experiment. Assessments will be taken immediately after functional exercise begins (T0), 5 min (T1) after functional exercise begins, and 5 min after functional exercise has finished (T2). Patients will be randomly allocated between a treatment group (A) and a control group (B) in a ratio of 1:1. Primary outcome, including pain severity in the procedure, will be taken for each group. Secondary outcomes include blood pressure, heart rate, oxygen saturation, side effects, knee joint range of motion, Knee Society Score (KSS), rescue analgesia need, and satisfaction from both therapists and patients. Discussion This study will focus on exploring a fast and efficient analgesic for patients who are doing functional exercise after total knee arthroplasty. Our previous studies suggested that the prefixed nitrous oxide/oxygen mixture was an efficacious analgesic for the management of burn-dressing pain and breakthrough cancer pain. The results of this study should provide a more in-depth insight into the effects of this analgesic method. If this treatment proves successful, it could be implemented widely for patients doing functional exercise in the rehabilitation department. Trial registration ChiCTR-INR-17012891. Registered on 6 October 2017. Electronic supplementary material The online version of this article (10.1186/s13063-019-3472-7) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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