Development of a virtual spacer to support the decision for the placement of an implantable rectum spacer for prostate cancer radiotherapy

Autor: Philippe Lambin, Sean Walsh, Ben G. L. Vanneste, Wouter van Elmpt, Yvonka van Wijk, Skadi van der Meer, Michael Pinkawa, Bram Ramaekers
Přispěvatelé: Promovendi ODB, Radiotherapie, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, RS: CAPHRI - R2 - Creating Value-Based Health Care, MUMC+: KIO Kemta (9)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Cost effectiveness
Cost-Benefit Analysis
medicine.medical_treatment
Balloon
Hydrogel
Polyethylene Glycol Dimethacrylate
030218 nuclear medicine & medical imaging
Prostate cancer
0302 clinical medicine
TUMOR
NOMOGRAMS
NTCP models
Radiotherapy Dosage
MEN
Prostheses and Implants
Hematology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
SURVIVAL
Radiology
SET
GY
medicine.medical_specialty
Implantable rectum spacer
Rectum
Decision Support Techniques
03 medical and health sciences
medicine
Humans
Radiology
Nuclear Medicine and imaging
Radiation Injuries
Radiotherapy
business.industry
Radiotherapy Planning
Computer-Assisted
Prostatic Neoplasms
Dose-Response Relationship
Radiation
Nomogram
medicine.disease
Surgery
Decision support
Radiation therapy
INTENSITY-MODULATED RADIOTHERAPY
Cost-effectiveness
Radiotherapy
Intensity-Modulated
Implant
Rectal Balloon
Tomography
X-Ray Computed
business
Zdroj: Radiotherapy and Oncology, 125(1), 107-112. Elsevier Ireland Ltd
ISSN: 0167-8140
DOI: 10.1016/j.radonc.2017.07.026
Popis: Introduction: Previous studies have shown that the implantable rectum spacer (IRS) is not beneficial for all patients. A virtual IRS (V-IRS) was constructed to help identify the patients for whom it is cost-effective to implant an IRS, and its viability as a tool to tailor the decision of an IRS implantation to be beneficial for the specified patient was assessed. Please watch animation: (https://www.youtube.comiwatch?v=tDlagSXMKqw)Materials and methods: The V-IRS was tested on 16 patients: 8 with a rectal balloon implant (RBI) and 8 with a hydrogel spacer. A V-IRS was developed using 7 computed tomography (CT) scans of patients with a RBI. To examine the V-IRS, CT scans before and after the implantation of an IRS were used. IMRT plans were made based on CT scans before the IRS, after IRS and with the V-IRS, prescribing 70 Gray (Gy) to the planning target volume. Toxicity was accessed using externally validated normal tissue complication probability (NTCP) models, and the Cost-effectiveness was analyzed using a published Markov model.Results: The rectum volume receiving 75 Gy (V75) were improved by both the IRS and the V-IRS with on average 4.2% and 4.3% respectively. The largest NTCP reduction resulting from the IRS and the V-IRS was 4.0% and 3.9% respectively. The RBI was cost-effective for 1 out of 8 patients, and the hydrogel was effective for 2 out of 8 patients, and close to effective for a third patient. The classification accuracy of the model, regarding cost-effectiveness, was 100%.Conclusion: The V-IRS approach in combination with a toxicity prediction model and a cost-effectiveness analyses is a promising basis for a decision support tool for the implantation of either a hydrogel spacer or a rectum balloon implant. (C) 2017 The Authors. Published by Elsevier Ireland Ltd.
Databáze: OpenAIRE
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