Additional file 2: of SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia

Autor: Pérez-Fernández, Alejandro, López-Ruano, Guillermo, Prieto-Bermejo, Rodrigo, Ijurko, Carla, Díez-Campelo, María, Sánchez-Guijo, Fermín, Hernández-Hernández, Ángel
Rok vydání: 2019
DOI: 10.6084/m9.figshare.7724138.v1
Popis: Figure S1. Chemical inhibition of SHP1 and SHP2 favors the differentiation of HEL cells. Levels of CD41 and CD61 surface markers in HEL cells 48 h after 4h incubation with the indicated inhibitors of SHP1 and SHP2. Figure S2. Chemical inhibition of SHP1 and SHP2 potentiates morphological changes of PMA in HL-60 cells. Representative pictures of May-Grünwald-Giemsa stained cytospins of HL-60 cells after 48 h treatment with PRS, NSC and their combination. Scale bar: 10 μm. Figure S3. AML cell lines are differentially responsive to PRS and NSC. A) Dose-response curves of HL-60 cells treated with PRS and NSC during 48 h. B) Dose-response curves of AML cell lines different from HL-60 treated with PMA and NSC during 48 h. (DOCX 509 kb)
Databáze: OpenAIRE