Effects of insulin and leptin in the ventral tegmental area and arcuate hypothalamic nucleus on food intake and brain reward function in female rats
Autor: | Hidetaka Yamada, Jessica A. Rogers, Lu W. Corrie, Adrie W. Bruijnzeel |
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Rok vydání: | 2011 |
Předmět: |
Leptin
medicine.medical_specialty Microinjections medicine.medical_treatment Adipokine Stimulation Article Rats Sprague-Dawley Eating Behavioral Neuroscience Self Stimulation Reward Internal medicine medicine Animals Hypoglycemic Agents Insulin Arc (protein) Ventral Tegmental Area digestive oral and skin physiology Arcuate Nucleus of Hypothalamus Brain Electrodes Implanted Rats Ventral tegmental area Endocrinology medicine.anatomical_structure Hypothalamus Conditioning Operant Female Brain stimulation reward Psychology psychological phenomena and processes |
Zdroj: | Behavioural Brain Research. 219:254-264 |
ISSN: | 0166-4328 |
Popis: | There is evidence for a role of insulin and leptin in food intake, but the effects of these adiposity signals on the brain reward system are not well understood. Furthermore, the effects of insulin and leptin on food intake in females are underinvestigated. These studies investigated the role of insulin and leptin in the ventral tegmental area (VTA) and the arcuate hypothalamic nucleus (Arc) on food intake and brain reward function in female rats. The intracranial self-stimulation procedure was used to assess the effects of insulin and leptin on the reward system. Elevations in brain reward thresholds are indicative of a decrease in brain reward function. The bilateral administration of leptin into the VTA (15-500 ng/side) or Arc (15-150 ng/side) decreased food intake for 72 h. The infusion of leptin into the VTA or Arc resulted in weight loss during the first 48 (VTA) or 24 h (Arc) after the infusions. The administration of insulin (0.005-5 mU/side) into the VTA or Arc decreased food intake for 24 h but did not affect body weights. The bilateral administration of low, but not high, doses of leptin (15 ng/side) or insulin (0.005 mU/side) into the VTA elevated brain reward thresholds. Neither insulin nor leptin in the Arc affected brain reward thresholds. These studies suggest that a small increase in leptin or insulin levels in the VTA leads to a decrease in brain reward function. A relatively large increase in insulin or leptin levels in the VTA or Arc decreases food intake. |
Databáze: | OpenAIRE |
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