The significance of calprotectin, CD147, APOA4 and DJ-1 in non-invasive detection of urinary bladder carcinoma
| Autor: | Tomáš Hanuš, Roman Sobotka, Kateřina Levová, Tomáš Zima, Marta Kalousová, L Vavrova, Michael Pešl, Viktor Soukup, Otakar Čapoun |
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| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
medicine.medical_specialty Apolipoprotein B Urinary system Protein Deglycase DJ-1 Urology Disease Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Cytology medicine Biomarkers Tumor Humans Apolipoproteins A Urinary bladder Bladder cancer medicine.diagnostic_test biology business.industry Cystoscopy medicine.disease medicine.anatomical_structure Oncology Urinary Bladder Neoplasms 030220 oncology & carcinogenesis biology.protein Basigin Calprotectin Neoplasm Recurrence Local business Leukocyte L1 Antigen Complex |
| Zdroj: | Neoplasma. 66(6) |
| ISSN: | 0028-2685 |
| Popis: | Aim of the study is to define the diagnostic accuracy of selected urinary protein biomarkers in the non-invasive detection of primary and recurrent urothelial carcinoma of the urinary bladder. The urinary levels of calprotectin, CD147, APOA4 and protein deglycase DJ-1 were examined in 255 individuals, including 60 controls with non-malignant urological disease, 61 patients with a history of urinary bladder cancer with negative cytology and negative cystoscopy and 134 patients with urinary bladder cancer. Urinary concentrations of biomarkers were determined by Enzyme-Linked Immunosorbent Assay (ELISA). During the follow-up of patients with non-muscle invasive bladder cancer (NMIBC), a group of 44 patients with cancer recurrence was compared to the group of 61 patients with a history of NMIBC but with no evidence of disease. Urinary concentrations of the evaluated markers did not reveal any significant difference between these groups. During the primary diagnosis, a group of 90 patients with primary bladder cancer and 60 subjects with benign disease were compared. Urinary levels of CD147 were not significantly higher in patients with tumors. The greatest diagnostic accuracy was observed in APOA4 (sensitivity 55.6, specificity 83.3, AUC 0.75), and lesser in calprotectin (sensitivity 39.4, specificity 87.7, AUC 0.66) and in DJ-1 (sensitivity 61.1, specificity 66.7, AUC 0.64), respectively. Apolipoprotein A4 may be used potentially as a supplemental urinary marker in the diagnosis of primary bladder cancer. |
| Databáze: | OpenAIRE |
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