Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?
| Autor: | Bengu Cevirgen Cemil, Demet Yilmazer, Hatice Atas, Fatma Pelin Cengiz, Filiz Canpolat, Murat Alper, Muzeyyen Gonul |
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| Přispěvatelé: | CENGİZ, Fatma Pelin |
| Rok vydání: | 2017 |
| Předmět: |
lcsh:Internal medicine
Original Paper skin endocrine system lichen planus receptors Dermatology lcsh:RL1-803 corticotropin-releasing hormone hypothalamo-hypophyseal system Cemil B. Yilmazer D. Atas H. Cengiz F. P. Canpolat F. Alper M. Gonul M. -Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?- Postepy dermatologii i alergologii cilt.34 ss.322-327 2017 lcsh:Dermatology Immunology and Allergy skin. Introduction lcsh:RC31-1245 hormones hormone substitutes and hormone antagonists |
| Zdroj: | Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii Advances in Dermatology and Allergology, Vol 34, Iss 4, Pp 322-327 (2017) |
| ISSN: | 1642-395X |
| DOI: | 10.5114/ada.2017.69311 |
| Popis: | Introduction: Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis. Aim: To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP. Material and methods: Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group. Results: The comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls (p < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients. Conclusions: Our study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions. |
| Databáze: | OpenAIRE |
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