A Designed Approach to Enantiodivergent Enamine Catalysis
| Autor: | Mathew J. Vetticatt, Juliet macharia, Gary B. Evans, Jennifer S. Hirschi, Yun Hong, Victor Wambua, Lawrence Harris |
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| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Chemistry Enantioselective synthesis Rational design General Medicine General Chemistry 010402 general chemistry 01 natural sciences Aldehyde Catalysis 0104 chemical sciences Enamine chemistry.chemical_compound Aldol reaction Organocatalysis Organic chemistry Amine gas treating |
| Zdroj: | Angewandte Chemie International Edition. 56:8756-8760 |
| ISSN: | 1433-7851 |
| Popis: | The rational design and implementation of enantiodivergent enamine catalysis is reported. A simple secondary amine catalyst, 2-methyl-l-proline, and its tetrabutylammonium salt function as an enantiodivergent catalyst pair delivering the enantiomers of α-functionalized aldehyde products in excellent enantioselectivities. This novel concept of designed enantiodivergence is applied to the enantioselective α-amination, aldol, and α-aminoxylation/α-hydroxyamination reactions of aldehydes. |
| Databáze: | OpenAIRE |
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