The effects of the GABA antagonist bicuculline on cocaine self-administration in rats exposed to lead during gestation/lactation
| Autor: | Angelica Rocha, Gerald R. Bratton, Jack R. Nation, Aaron L. Cardon, Rodrigo Valles |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Clinical Biochemistry Self Administration Pharmacology Bicuculline Toxicology Biochemistry GABA Antagonists Rats Sprague-Dawley Cocaine-Related Disorders Eating Behavioral Neuroscience chemistry.chemical_compound Reward Pregnancy Internal medicine medicine Animals GABA-A Receptor Antagonists Neurotransmitter Biological Psychiatry Dose-Response Relationship Drug business.industry GABAA receptor Local anesthetic Alkaloid Body Weight Antagonist Rats Endocrinology Animals Newborn Lead chemistry Prenatal Exposure Delayed Effects Conditioning Operant Female business Self-administration Breast feeding medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 80:611-619 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/j.pbb.2005.01.011 |
| Popis: | The present investigation examined the effects of perinatal lead exposure on cocaine self-administration following a GABAA antagonist pretreatment. Female rats were exposed to either 0 or 16 mg lead daily for 30 days prior to breeding with unexposed males. Beginning on postnatal day (PND) 75, control (N=10) and lead-exposed (N=8) animals were trained to self-administer 0.50 mg/kg cocaine intravenously (IV). After stable responding was established, animals were tested at 0.03 and 0.06 mg/kg cocaine delivered intravenously (IV), combined with intraperitoneal (IP) administration of either saline, 0.50, 1.00 or 2.00 mg/kg bicuculline (a GABAA antagonist). The results showed that control animals increased self-administration responding at a cocaine dose of 0.06 mg/kg as bicuculline dose increased. Lead-exposed animals exhibited an opposite pattern, i.e., a decrease in active (cocaine) lever responding occurred as the bicuculline dose was increased. Results at the 0.03 mg/kg cocaine dose failed to show group separation, or significant changes consequent to the bicuculline pretreatment. The data suggest that GABA antagonism results in increased reward potency of a low dose of cocaine and further, that this effect is differentially expressed in animals exposed to perinatal lead. |
| Databáze: | OpenAIRE |
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