Oxidative stress inhibition by resveratrol in alcohol-dependent mice
| Autor: | Claudio Carere, Cristiano Bello, Mauro Ceccanti, Marco Fiore, Stefania Ciafrè, Giampiero Ferraguti, Rosanna Mancinelli, Massimo Ralli, Marisa Patrizia Messina, Valentina Carito, Carla Petrella, Fausta Natella, Antonio Greco |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Antioxidant Endocrinology Diabetes and Metabolism Metabolite medicine.medical_treatment Radical 030209 endocrinology & metabolism Alcohol Resveratrol Pharmacology medicine.disease_cause Antioxidants 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Neurotrophic factors Stilbenes medicine Ingestion Animals 030109 nutrition & dietetics Nutrition and Dietetics Ethanol food and beverages Alcoholism Oxidative Stress chemistry Addiction Alcohol use disorders Antioxidant polyphenols Resveratrol BDNF Oxidative stress |
| Zdroj: | Nutrition (Burbank Los Angel. Cty. Calif.) 79-80 (2020). doi:10.1016/j.nut.2020.110783 info:cnr-pdr/source/autori:Petrella C.; Carito V.; Carere C.; Ferraguti G.; Ciafre S.; Natella F.; Bello C.; Greco A.; Ralli M.; Mancinelli R.; Messina M.P.; Fiore M.; Ceccanti M./titolo:Oxidative stress inhibition by resveratrol in alcohol-dependent mice/doi:10.1016%2Fj.nut.2020.110783/rivista:Nutrition (Burbank Los Angel. Cty. Calif.)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:79-80 |
| ISSN: | 1873-1244 |
| DOI: | 10.1016/j.nut.2020.110783 |
| Popis: | Objectives Uncontrolled ingestion of alcohol has dramatic consequences on the entire organism that are also associated with the oxidation process induced by alcohol and elevate radical oxygen species. Resveratrol, a nonflavonoid phenol, shows well-documented antioxidant properties. We investigated the potential antioxidant ability of this natural compound in a mouse model of alcohol addiction. Methods We administered (per os) for 60 d 10 mg · kg–1 · d–1 of resveratrol in alcoholic adult male mice. Oxidative stress was evaluated by measuring serum–free oxygen radicals defense and free oxygen radical levels. Resveratrol metabolites were measured in the serum of mice that were administered with resveratrol. Finally, the effect of resveratrol on the alcohol-induced alteration of brain-derived neurotrophic factors (BDNF) in the liver was investigated. Results Prolonged consumption of resveratrol strongly counteracts serum radical oxygen species formation caused by chronic alcohol intake without effects on natural, free oxygen radical defense. The presence of resveratrol metabolites in the serum only of animals supplemented with resveratrol potentiates the evidence that the antioxidant effect observed is due to the ingestion of the natural compound. Moreover, resveratrol supplementation can counteract alcohol-induced BDNF elevation in the liver, which is the main target of organ alcohol-induced damage. Conclusions The consumption of resveratrol through metabolite formation may play a protective role by decreasing free radical formation and modulating the BDNF involved in hepatic disruption induced by chronic alcohol consumption. Further investigation into the mechanism underlying the protective effect could reinforce the potential use of resveratrol as a dietary supplement to prevent damage associated with chronic alcohol abuse. |
| Databáze: | OpenAIRE |
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