Fetal immunoglobulin synthesis following maternal immunosuppression
| Autor: | Irwin R. Merkatz, Lars L. Cederqvist, Stephen D. Litwin |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Graft Rejection medicine.medical_treatment Immunoglobulins Azathioprine Immunoglobulin D Fetus Immune system Pregnancy medicine Humans Lupus Erythematosus Systemic Transplantation Homologous Maternal-Fetal Exchange Kidney transplantation Immunosuppression Therapy biology business.industry Immunity Infant Newborn Obstetrics and Gynecology Immunosuppression medicine.disease Kidney Transplantation Pregnancy Complications Cord blood Immunology biology.protein Prednisone Female Antibody business medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 129:687-690 |
| ISSN: | 0002-9378 |
| Popis: | Cord blood levels of immunoglobulin (Ig) A, IgM, IgD, and IgG classes and IgA 1 and IgA 2 subclasses were determined in the offspring of seven mothers who received azathioprine and/or prednisone during the entire pregnancy. Five of these women received the immunosuppressive therapy following kidney transplantation, and two received immunosuppressive therapy because of disseminated systemic lupus erythematosus. The fetuses appeared to have intact humeral immune function in that they had normal cord blood immunoglobulin concentrations and in one case responsded with increased synthesis of IgA and IgM following premature rupture of the membranes. |
| Databáze: | OpenAIRE |
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