A Pilot Study of the Impact of Microwave Ablation on the Dielectric Properties of Breast Tissue
| Autor: | R. Owen Mays, Nader Behdad, James F. Sawicki, Barry D. Van Veen, Lee G. Wilke, Josephine Harter, Amanda Schulman, Susan C. Hagness, Luz Maria Neira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Ablation Techniques
Percutaneous medicine.medical_treatment Adipose tissue Breast Neoplasms Pilot Projects Dielectric Electric Capacitance lcsh:Chemical technology Biochemistry Article 030218 nuclear medicine & medical imaging Analytical Chemistry 03 medical and health sciences 0302 clinical medicine Breast cancer Humans Medicine lcsh:TP1-1185 Electrical and Electronic Engineering Microwaves skin and connective tissue diseases Instrumentation dielectric spectroscopy Mastectomy Breast tissue business.industry Microwave ablation Electric Conductivity Prophylactic Mastectomy Ablation medicine.disease Atomic and Molecular Physics and Optics breast cancer treatment 030220 oncology & carcinogenesis microwave ablation Female sense organs business Biomedical engineering |
| Zdroj: | Sensors Volume 20 Issue 19 Sensors, Vol 20, Iss 5698, p 5698 (2020) Sensors (Basel, Switzerland) |
| ISSN: | 1424-8220 |
| DOI: | 10.3390/s20195698 |
| Popis: | Percutaneous microwave ablation (MWA) is a promising technology for patients with breast cancer, as it may help treat individuals who have less aggressive cancers or do not respond to targeted therapies in the neoadjuvant or pre-surgical setting. In this study, we investigate changes to the microwave dielectric properties of breast tissue that are induced by MWA. While similar changes have been characterized for relatively homogeneous tissues, such as liver, those prior results are not directly translatable to breast tissue because of the extreme tissue heterogeneity present in the breast. This study was motivated, in part by the expectation that the changes in the dielectric properties of the microwave antenna&rsquo s operation environment will be impacted by tissue composition of the ablation target, which includes not only the tumor, but also its margins. Accordingly, this target comprises a heterogeneous mix of malignant, healthy glandular, and adipose tissue. Therefore, knowledge of MWA impact on breast dielectric properties is essential for the successful development of MWA systems for breast cancer. We performed ablations in 14 human ex-vivo prophylactic mastectomy specimens from surgeries that were conducted at the UW Hospital and monitored the temperature in the vicinity of the MWA antenna during ablation. After ablation we measured the dielectric properties of the tissue and analyzed the tissue samples to determine both the tissue composition and the extent of damage due to the ablation. We observed that MWA induced cell damage across all tissue compositions, and found that the microwave frequency-dependent relative permittivity and conductivity of damaged tissue are lower than those of healthy tissue, especially for tissue with high fibroglandular content. The results provide information for future developments on breast MWA systems. |
| Databáze: | OpenAIRE |
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