Cerebellar re-encoding of self-generated head movements
| Autor: | Dugué, Guillaume P, Tihy, Matthieu, Gourévitch, Boris, Léna, Clément |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
cerebellum
Head (linguistics) QH301-705.5 Science Kinematics 03 medical and health sciences 0302 clinical medicine Encoding (memory) Animals head direction Sensitivity (control systems) Gravity Sensing Biology (General) Orientation Spatial 030304 developmental biology Physics Vestibular system self-motion 0303 health sciences vestibular system Rats gravity Purkinje cells Head Movements Cerebellar vermis Rat Head movements Medicine Neuroscience 030217 neurology & neurosurgery Research Article Cerebellar Vermis Reference frame |
| Zdroj: | eLife, Vol 6 (2017) eLife |
| Popis: | Head movements are primarily sensed in a reference frame tied to the head, yet they are used to calculate self-orientation relative to the world. This requires to re-encode head kinematic signals into a reference frame anchored to earth-centered landmarks such as gravity, through computations whose neuronal substrate remains to be determined. Here, we studied the encoding of self-generated head movements in the rat caudal cerebellar vermis, an area essential for graviceptive functions. We found that, contrarily to peripheral vestibular inputs, most Purkinje cells exhibited a mixed sensitivity to head rotational and gravitational information and were differentially modulated by active and passive movements. In a subpopulation of cells, this mixed sensitivity underlay a tuning to rotations about an axis defined relative to gravity. Therefore, we show that the caudal vermis hosts a re-encoded, gravitationally polarized representation of self-generated head kinematics in freely moving rats. DOI: http://dx.doi.org/10.7554/eLife.26179.001 |
| Databáze: | OpenAIRE |
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