Deltamethrin Intranasal administration induces memory, emotional and tyrosine hydroxylase immunoreactivity alterations in rats
| Autor: | Regina H. Silva, Katty A.A.L. Medeiros, Lívia C.R.F. Lins, José R. Santos, Auderlan M. Gois, Pollyana Caldeira Leal, Marco Aurelio M. Freire, Murilo Marchioro, José M.M. Bispo, Rovena C.G.J. Engelberth, Marina F. Souza, Alessandra Mussi Ribeiro |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Tyrosine 3-Monooxygenase Emotions Substantia nigra Striatum Catalepsy Motor Activity 03 medical and health sciences Random Allocation 0302 clinical medicine Parkinsonian Disorders Dopamine Memory Internal medicine Nitriles Pyrethrins Medicine Animals Pesticides Rats Wistar Pars Compacta Administration Intranasal Memory Disorders Tyrosine hydroxylase business.industry Pars compacta General Neuroscience Dopaminergic Ventral Tegmental Area medicine.disease Ventral tegmental area 030104 developmental biology medicine.anatomical_structure Endocrinology business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Brain research bulletin. 142 |
| ISSN: | 1873-2747 |
| Popis: | Parkinson's disease (PD) is a neurodegenerative disease related to the dopaminergic system. The etiology is not fully understood, but it is known that PD is a multifactorial disease that involves genetic and environmental factors, including pesticides. One of these, Deltamethrin (DM), has been widely used for vector control in crops, farming, veterinary medicine and domestic pest control. The purpose of the present study was to investigate the effect of DM repeated administration on motor, cognitive and emotional behavior and dopaminergic parameters. Male Wistar rats received 3 intranasal (i.n.) injections of 100 μL (50 μL/nostril) of DM 0.5 μg/μl or Vehicle (saline solution 0.9%), one injection per week. We observed that DM caused memory (novel object recognition task) and emotion (contextual conditioned fear) alterations accompanied by reduction of TH immunoreactivity in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA), and increase of TH immunoreactivity in the dorsal striatum. Motor alterations (catalepsy and open field task) were not observed throughout treatment. These findings suggest a possible early disruption of the dopaminergic pathway caused by repeated DM exposure, similar to that observed in early stages of PD. |
| Databáze: | OpenAIRE |
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