Brain thiamine, its phosphate esters, and its metabolizing enzymes in alzheimer's disease
| Autor: | Frank Mastrogiacomo, Lucien Bettendorff, Thierry Grisar, Stephen J. Kish |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Vitamin
medicine.medical_specialty Time Factors Thiamine Triphosphate chemistry.chemical_compound Thiamine triphosphatase Alzheimer Disease Internal medicine mental disorders medicine Humans Ketoglutarate Dehydrogenase Complex Thiamine Aged Brain Chemistry Cerebral Cortex chemistry.chemical_classification Thiamin Pyrophosphokinase Chemistry Age Factors nutritional and metabolic diseases food and beverages Metabolism Thiamine monophosphate medicine.disease Thiamine Monophosphate Acid Anhydride Hydrolases nervous system diseases medicine.anatomical_structure Endocrinology Enzyme Neurology Thiamin-Triphosphatase Cerebral cortex Case-Control Studies Autopsy Neurology (clinical) Thiamine Pyrophosphate Alzheimer's disease human activities |
| Zdroj: | Annals of Neurology. 39:585-591 |
| ISSN: | 1531-8249 0364-5134 |
| Popis: | Clinical data suggest that high-dose thiamine (vitamin B1) may have a mild beneficial effect in some patients with Alzheimer's disease (AD). Since this action could be related to a brain thiamine deficiency, we measured directly levels of free (nonphosphorylated) thiamine and its phosphate esters, thiamine monophosphate and thiamine diphosphate (TDP), and activities of three TDP-metabolizing enzymes (thiamine pyrophosphokinase, thiamine diphosphatase, and thiamine triphosphatase) in autopsied cerebral cortex of 18 patients with AD and 20 matched controls. In the AD group, mean levels of free thiamine and its monophosphate ester were normal, whereas levels of TDP were significantly reduced by 18 to 21% in all three cortical brain areas examined. Activities of the TDP-metabolizing enzymes were normal in the AD group, suggesting that decreased TDP is not due to altered levels of these enzymes. The TDP decrease could be explained by a cerebral cortical deficiency in AD of ATP, which is needed for TDP synthesis. Although the magnitude of the TDP reduction is slight, a chronic subclinical TDP deficiency could contribute to impaired brain function in AD and might provide the basis for the modest improvement by thiamine in cognitive status of some patients with AD. |
| Databáze: | OpenAIRE |
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