Why the histocompatibility system exists and how transplant surgeons can xenograft without rejection
| Autor: | D. D. Adams |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Graft Rejection
business.industry Transplantation Heterologous General Medicine Virology Histocompatibility Immune tolerance Transplantation medicine.anatomical_structure Immune system Antigen Immunity Immunology Immune Tolerance medicine Animals Humans Cytotoxic T cell Bone marrow business Antigens Viral Bone Marrow Transplantation T-Lymphocytes Cytotoxic |
| Zdroj: | QJM. 104:767-769 |
| ISSN: | 1460-2393 1460-2725 |
| DOI: | 10.1093/qjmed/hcr051 |
| Popis: | The histocompatibility system is responsible for the rejection of allografts. The system exists to counter the explosive speed of viral replication by directing the defensive immune attack by cytotoxic T cells on to histocompatibility antigens on the infected cell's surface. This enables destruction of the virus factories before the cytotoxic T cells are swamped by the myriad numbers of new virions, a thousand coming from each infected cell every 10 h. The immunity system mistakes alloantigens for virus-infected host cells that need swift destruction. For transplantation, Sykes has improved Kaplan's technique by adding recipient bone marrow cells to the donor ones injected for reconstitution of the recipient after immune ablation. This technique should enable the use of xenografts from pigs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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