Alpha2 adrenergic amines, adenosine and prostaglandis inhibit lipolysis and cyclic AMP accumulation in hamster adipocytes in the absence of extracellular sodium
| Autor: | John N. Fain, J. Adolfo García-Sáinz, Shih-Ying Li |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Adenosine Adenosine Deaminase Lipolysis Sodium Adenylate kinase chemistry.chemical_element Cyclase Clonidine General Biochemistry Genetics and Molecular Biology Adenosine deaminase Adrenocorticotropic Hormone Theophylline Cricetinae Internal medicine Cyclic AMP medicine Animals General Pharmacology Toxicology and Pharmaceutics Prostaglandin E2 Mesocricetus biology Chemistry Prostaglandins E AMP deaminase General Medicine Endocrinology Adipose Tissue Phenylisopropyladenosine biology.protein medicine.drug |
| Zdroj: | Life Sciences. 28:401-406 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(81)90085-0 |
| Popis: | The accumulation of cyclic AMP due to adenosine deaminase plus theophylline and either isoproterenol or ACTH in the presence of adenosine deaminase plus theophylline, was inhibited by clonidine, N6-(phenylisopropyl)-adenosine and prostaglandin E2. The inhibition was nearly identical in medium containing sodium ions or in medium in which sodium and its accompanying anion were substituted by an isosmotic amount of sucrose. Consistent with this, lipolysis induced by adenosine deaminase and theophylline was significantly inhibited by clonidine, N6-(phenylisopropyl)-adenosine and prostaglandin E2 regardless of the presence or absence of Na+ in the medium. The results do not support the suggestion that extracellular Na+ is required for the regulation of cyclic AMP levels by hormones and neurotransmitters that inhibit adenylate cyclase. |
| Databáze: | OpenAIRE |
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