Pheomelanogenesis is promoted at a weakly acidic pH
| Autor: | Miu Watanabe, Kenta Nakao, Kazumasa Wakamatsu, Ayano Nagao, Shosuke Ito |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Time Factors Tyrosinase Dermatology Benzothiazine Medicinal chemistry General Biochemistry Genetics and Molecular Biology Melanin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cysteine Tyrosine Melanosome Melanins Melanosomes Monophenol Monooxygenase Hydrogen-Ion Concentration Cysteinyldopa Dihydroxyphenylalanine 030104 developmental biology Oncology chemistry Biochemistry 030220 oncology & carcinogenesis Dopachrome Acids Oxidation-Reduction |
| Zdroj: | Pigment Cell & Melanoma Research. 30:372-377 |
| ISSN: | 1755-1471 |
| DOI: | 10.1111/pcmr.12587 |
| Popis: | The diversity of pigmentation in the skin, hair, and eyes of humans has been largely attributed to the diversity of pH in melanosomes with an acidic pH being proposed to suppress melanin production, especially eumelanogenesis. We previously showed that an acidic pH greatly suppresses the late stage of eumelanogenesis after the dopachrome stage. The oxidation of tyrosine by tyrosinase in the presence of cysteine forms cysteinyldopa isomers, which are further oxidized to give rise to pheomelanin via benzothiazine intermediates. However, how those steps are controlled by pH has not been characterized. We therefore examined whether pheomelanin synthesis is chemically promoted at an acidic pH. We found that pheomelanin production either from dopa or tyrosine in the presence of cysteine by tyrosinase was greatest at pH values of 5.8-6.3, while eumelanin production was suppressed at pH 5.8. This suggests that mixed melanogenesis is chemically shifted to more pheomelanic states at a weakly acidic pH. |
| Databáze: | OpenAIRE |
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