Failure to Find an Association Between Hepatitis C Virus and Thyroid Autoimmunity
| Autor: | G. Kudesia, A.P. Weetman, G. Ball, R. A. Metcalfe |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male endocrine system endocrine system diseases Endocrinology Diabetes and Metabolism Hepatitis C virus Enzyme-Linked Immunosorbent Assay Antibodies Viral medicine.disease_cause Iodide Peroxidase Thyroiditis Autoimmune thyroiditis Endocrinology medicine Humans Risk factor Autoantibodies Hepatitis biology business.industry Thyroiditis Autoimmune Hepatitis C medicine.disease Virology Anti-thyroid autoantibodies Immunology biology.protein Female Antibody business |
| Zdroj: | Thyroid. 7:421-424 |
| ISSN: | 1557-9077 1050-7256 |
| DOI: | 10.1089/thy.1997.7.421 |
| Popis: | A high frequency of hepatitis C antibodies has been reported from France in patients with autoimmune thyroiditis. Two cases of Hashimoto's thyroiditis in association with chronic active hepatitis and hepatitis C infection have also been reported. We have examined this potential association in 46 patients with autoimmune hypothyroidism and found that 16 apparently had hepatitis C antibodies in one of the two commercially available enzyme-linked immunosorbent assays (ELISA), but all patients were negative in a confirmatory commercially available recombinant immunoblot assay (RIBA-3) indicating that none of the patients were truly positive for hepatitis C antibodies. We also tested sera from 111 patients with proven hepatitis C infection and found no increased prevalence of thyroid autoantibodies. These results suggest that hepatitis C infection is not a risk factor for the development of thyroid autoimmunity in the United Kingdom. |
| Databáze: | OpenAIRE |
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