Treatment of Hypoxemia During One-Lung Ventilation Using Intravenous Almitrine
| Autor: | M. Moutafis, Stéphanie Monsel, Nicolas Dalibon, Ngai Liu, Jean-Dominique Law-Koune, Marc Fischler |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Almitrine Adolescent Respiratory System Agents Hypoxemia Sufentanil Double-Blind Method Humans Medicine Anesthesia Prospective Studies Cardiac Output Respiratory system Hypoxia Prospective cohort study Aged Aged 80 and over Lung business.industry Hemodynamics Middle Aged respiratory system Respiration Artificial respiratory tract diseases Anesthesiology and Pain Medicine medicine.anatomical_structure Breathing Female Blood Gas Analysis medicine.symptom business Propofol Echocardiography Transesophageal medicine.drug |
| Zdroj: | Anesthesia & Analgesia. :590-594 |
| ISSN: | 0003-2999 |
| Popis: | We performed this prospective randomized double-blinded study to assess the ability of almitrine to treat hypoxemia during one-lung ventilation (OLV). Twenty-eight patients were anesthetized with propofol, sufentanil, and atracurium; lung separation was achieved with a double-lumen tube. A transesophageal Doppler probe was inserted to evaluate cardiac index. If SpO(2) was equal to or decreased to95% during OLV (inspired fraction of oxygen of 0.6), patients were included in the study and received a placebo or almitrine (12 microg x kg(-1) x min(-1) for 10 min followed by 4 microg x kg(-1) x min(-1)) infusion until SpO(2) reached 90% or decreased to90% (exclusion from the study). Eighteen of the 28 patients were included and received either almitrine (n = 9) or a placebo (n = 9). Treatment was discontinued in 1 patient in the almitrine group and 6 in the placebo group (P0.05). Treatment was successful (SpO(2) remainingor=95% during OLV) in 8 patients in the almitrine group and 1 in the placebo group (P0.01). Heart rate, arterial blood pressure, and cardiac index did not change throughout the study, but we could obtain an adequate aortic blood flow signal in only half of the patients. Almitrine could be used to treat hypoxemia during OLV.IV almitrine improves oxygenation during one-lung ventilation without hemodynamic modification. Such treatment could be used when conventional ventilatory strategy fails to treat hypoxemia or cannot be used. |
| Databáze: | OpenAIRE |
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