Prognosis of Isolated First-Trimester Fetal Megacystis with Spontaneous Resolution
| Autor: | Catherine Egoroff, Anne-Gaël Cordier, Alexandra Benachi, Noémie Girard, Benjamin Viaris de Lesegno, Paul Bussière |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Embryology
medicine.medical_specialty Duodenum Urinary system Remission Spontaneous Urinary Bladder Spontaneous remission 03 medical and health sciences 0302 clinical medicine Pregnancy Fetal megacystis medicine Humans Radiology Nuclear Medicine and imaging 030212 general & internal medicine Retrospective Studies Gynecology Fetus 030219 obstetrics & reproductive medicine Urinary bladder business.industry Obstetrics Obstetrics and Gynecology Retrospective cohort study General Medicine Megacystis medicine.disease Prognosis Fetal Diseases Pregnancy Trimester First medicine.anatomical_structure Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Fetal diagnosis and therapy. 42(4) |
| ISSN: | 1421-9964 |
| Popis: | Objective: Fetal megacystis has a poor prognosis. During the first trimester, it is frequently associated with chromosomal abnormalities or multiple malformations, but can also be isolated and resolve spontaneously. In this study, our main objective was to determine the fetal and pediatric prognosis in this particular situation. Methods: This was a retrospective multicenter study. We describe the cases referred to our fetal medicine centers and also cases previously reported in the international literature. Results: Five cases were referred to our fetal medicine centers. After spontaneous resolution of megacystis, close ultrasound follow-up revealed urinary tract abnormalities in all cases. These abnormalities were all transient. After birth, 1 of the children developed a mild ureteropelvic junction obstruction. Pediatric follow-up was normal for the other children. Our 5 cases plus 79 in the literature mean that 84 cases of isolated first-trimester fetal megacystis with spontaneous resolution have been reported to date. The risk of chromosomal abnormality was 2.4% (2/84) and pediatric follow-up was normal in 96.4% of cases (81/84). Conclusion: Even when isolated first-trimester fetal megacystis resolves spontaneously, fetal karyotype analysis and close prenatal ultrasound follow-up should be performed. When there is no chromosomal abnormality, the renal pediatric prognosis seems to be good. |
| Databáze: | OpenAIRE |
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