The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration
| Autor: | Cecilia Vera, Auriane Maïza, Olivier Stettler, Sandrine Chantepie, Minh Bao Huynh, Mohand Ouidir Ouidja, Dulce Papy-Garcia, Alexandre Fifre |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Amyloid Parkinson's disease Proteolysis Biophysics Protein aggregation Biochemistry Prion Proteins Prion Diseases Ciencias Biológicas 03 medical and health sciences Protein Aggregates Structural Biology In vivo Alzheimer Disease Genetics medicine Humans Receptor Molecular Biology Potential impact HEPARAN SULFATES medicine.diagnostic_test Chemistry Neurodegeneration NEURODEGENERATION Parkinson Disease Cell Biology Bioquímica y Biología Molecular medicine.disease In vitro Cell biology 030104 developmental biology Models Chemical ALZHEIMER'S DISEASE alpha-Synuclein Heparitin Sulfate PROTEIN AGGREGATION PARKINSON'S DISEASE PRION DISEASES CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | FEBS Letters |
| DOI: | 10.1002/1873-3468.13082 |
| Popis: | Neurodegenerative disorders, such as Alzheimer´s, Parkinson´s, and prion diseases, are directly linked to the formation and accumulation of protein aggregates in the brain. These aggregates, principally made of proteins or peptides that clamp together after acquisition of β-folded structures, also contain heparan sulfates. Several lines of evidence suggest that heparan sulfates centrally participate in the protein aggregation process. In vitro, they trigger misfolding, oligomerization, and fibrillation of amyloidogenic proteins, such as Aβ, tau, α-synuclein, prion protein, etc. They participate in the stabilization of protein aggregates, protect them from proteolysis, and act as cell-surface receptors for the cellular uptake of proteopathic seeds during their spreading. This review focuses attention on the importance of heparan sulfates in protein aggregation in brain disorders including Alzheimer´s, Parkinson´s, and prion diseases. The presence of these sulfated polysaccharides in protein inclusions in vivo and their capacity to trigger protein aggregation in vitro strongly suggest that they might play critical roles in the neurodegenerative process. Further advances in glyco-neurobiology will improve our understanding of the molecular and cellular mechanisms leading to protein aggregation and neurodegeneration. Fil: Maïza, Auriane. Universite de Paris; Francia Fil: Chantepie, Sandrine. Universite de Paris; Francia Fil: Vera, Claudia Cecilia. Universite de Paris; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina Fil: Fifre, Alexandre. Universite de Paris; Francia Fil: Huynh, Minh Bao. Universite de Paris; Francia Fil: Stettler, Olivier. Universite de Paris; Francia Fil: Ouidja, Mohand Ouidir. Universite de Paris; Francia Fil: Papy Garcia, Dulce. Universite de Paris; Francia |
| Databáze: | OpenAIRE |
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