Transdiagnostic development of internalizing psychopathology throughout the life course up to age 45: a World Mental Health Surveys report
| Autor: | de Vries YA, Al-Hamzawi A, Alonso J, Andrade LH, Benjet C, Bruffaerts R, Bunting B, de Girolamo G, Florescu S, Gureje O, Haro JM, Karam A, Karam EG, Kawakami N, Kovess-Masfety V, Lee S, Mneimneh Z, Navarro-Mateu F, Ojagbemi A, Posada-Villa J, Scott K, Stagnaro JC, Torres Y, Xavier M, Zarkov ZN, Kessler RC, de Jonge P, WHO World Mental Health Survey collaborators |
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| Přispěvatelé: | Developmental Psychology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Population
Internalizing disorders 03 medical and health sciences 0302 clinical medicine medicine education Suicidal ideation Applied Psychology Depression (differential diagnoses) education.field_of_study business.industry Depression CIDI medicine.disease Mental health Comorbidity latent class growth analysis Latent class growth analysis 030227 psychiatry Psychiatry and Mental health depression internalizing disorders Life course approach Anxiety medicine.symptom business 030217 neurology & neurosurgery Clinical psychology Anxiety disorders |
| Zdroj: | PSYCHOLOGICAL MEDICINE r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname Psychological Medicine, 52, 2134-2143. Cambridge University Press |
| ISSN: | 0033-2917 |
| Popis: | BackgroundDepressive and anxiety disorders are highly comorbid, which has been theorized to be due to an underlying internalizing vulnerability. We aimed to identify groups of participants with differing vulnerabilities by examining the course of internalizing psychopathology up to age 45.MethodsWe used data from 24158 participants (aged 45+) in 23 population-based cross-sectional World Mental Health Surveys. Internalizing disorders were assessed with the Composite International Diagnostic Interview (CIDI). We applied latent class growth analysis (LCGA) and investigated the characteristics of identified classes using logistic or linear regression.ResultsThe best-fitting LCGA solution identified eight classes: a healthy class (81.9%), three childhood-onset classes with mild (3.7%), moderate (2.0%), or severe (1.1%) internalizing comorbidity, two puberty-onset classes with mild (4.0%) or moderate (1.4%) comorbidity, and two adult-onset classes with mild comorbidity (2.7% and 3.2%). The childhood-onset severe class had particularly unfavorable sociodemographic outcomes compared to the healthy class, with increased risks of being never or previously married (OR = 2.2 and 2.0, p < 0.001), not being employed (OR = 3.5, p < 0.001), and having a low/low-average income (OR = 2.2, p < 0.001). Moderate or severe (v. mild) comorbidity was associated with 12-month internalizing disorders (OR = 1.9 and 4.8, p < 0.001), disability (B = 1.1–2.3, p < 0.001), and suicidal ideation (OR = 4.2, p < 0.001 for severe comorbidity only). Adult (v. childhood) onset was associated with lower rates of 12-month internalizing disorders (OR = 0.2, p < 0.001).ConclusionsWe identified eight transdiagnostic trajectories of internalizing psychopathology. Unfavorable outcomes were concentrated in the 1% of participants with childhood onset and severe comorbidity. Early identification of this group may offer opportunities for preventive interventions. |
| Databáze: | OpenAIRE |
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