Research Progress on the Molecular Mechanism by Which Depression Affects Bone Metabolism
| Autor: | Xueyan Chen, Xuemei Zhang, Gao Haiming, Yaoge Deng, Zongchao Liu, D D Duan, Chenyi Huang, Kaili Zhao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell signaling Depression Mechanism (biology) Cell Biology General Medicine Bone healing Biology Bioinformatics Bone and Bones Bone remodeling 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Monoamine neurotransmitter 030220 oncology & carcinogenesis Genetics Molecular mechanism Animals Humans In patient Molecular Biology Depression (differential diagnoses) |
| Zdroj: | DNA and Cell Biology. 39:738-746 |
| ISSN: | 1557-7430 1044-5498 |
| DOI: | 10.1089/dna.2019.5284 |
| Popis: | Increasing evidence indicates that depression affects bone metabolism to some extent, but the specific mechanisms are still unclear. Numerous studies have confirmed that a variety of signaling molecules are involved in depression's impact on fracture healing, including serum monoamine neurotransmitters, cytokines, inflammatory markers, growth factors, and metabolites. This article comprehensively discusses the effects of depression-associated signaling molecules on bone metabolism and their underlying mechanisms to provide a basis for early preventive intervention for delayed fracture healing in patients with depression. |
| Databáze: | OpenAIRE |
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