Consistent Condom Use Increases the Regression Rate of Cervical Intraepithelial Neoplasia 2-3
| Autor: | Feja J. Voorhorst, Arnold J. Kruse, Kjell Løvslett, Bent Fiane, Jan P. A. Baak, Anais Malpica, Irene T Øvestad, Ane Cecilie Munk, Einar Gudlaugsson, Emiel A. M. Janssen |
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| Přispěvatelé: | Epidemiology and Data Science, CCA - Oncogenesis, Obstetrie & Gynaecologie, RS: GROW - School for Oncology and Reproduction |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Viral Diseases medicine.medical_specialty Multivariate analysis Clinical Research Design Epidemiology Science Gynecologic Infections Population Sexually Transmitted Diseases Uterine Cervical Neoplasms Cervical intraepithelial neoplasia Cohort Studies Condoms Humans Medicine Prospective Studies education Gynecology education.field_of_study Univariate analysis Multidisciplinary Norway business.industry Obstetrics Remission Induction Hazard ratio Gynecologic Cancers Obstetrics and Gynecology Uterine Cervical Dysplasia medicine.disease Sexual intercourse Infectious Diseases Oncology Hormonal contraception Women's Health Oncology Agents Female business Cancer Prevention Research Article Cohort study |
| Zdroj: | PLoS ONE, 7(9):e45114. Public Library of Science PLOS ONE, 7(9):e45114. Public Library of Science Munk, A C, Gudlaugsson, E, Malpica, A, Fiane, B, Lovslett, K I, Kruse, A, Ovestad, I T, Voorhorst, F J, Janssen, E A M & Baak, J P A 2012, ' Consistent Condom Use Increases the Regression Rate of Cervical Intraepithelial Neoplasia 2-3 ', PLoS ONE, vol. 7, no. 9, e45114 . https://doi.org/10.1371/journal.pone.0045114 PLoS ONE, Vol 7, Iss 9, p e45114 (2012) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0045114 |
| Popis: | ObjectiveCervical intraepithelial neoplasia grades 2-3 (CIN2-3) are usually treated by cone excision, although only 30% progress to cancer and 6-50% regress spontaneously. The aim of this study was to examine the influence of clinical factors like smoking habits, number of lifetime sexual partners, age at first sexual intercourse, sexual activity span and hormonal versus non-hormonal contraception type on the regression rate of CIN2-3.MethodsIn this prospective population-based cohort study 170 women aged 25-40 with abnormal cytology and colposcopy-directed biopsies showing first time onset CIN2-3 were consecutively included. The interval between biopsy and cone excision was standardized to minimum 12 weeks. Regression was defined as ≤ CIN1 in the cone biopsy.ResultsThe regression rate was 22%. Consistent condom use, defined as those women whose partners used condoms for all instances of sexual intercourse, was infrequent (n=20, 12%). In univariate analysis consistent condom use, hormonal contraception and age at first sexual intercourse significantly predicted regression. In a multivariate analysis only consistent condom use remained as an independent predictor of regression (regression rate 55%, p=0.001, hazard ratio=4.4).ConclusionConsistent condom use between punch biopsy and cone excision in first-time onset CIN2-3 patients significantly increases the regression rate. |
| Databáze: | OpenAIRE |
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