Anticonvulsant medications for panic disorder: a review and synthesis of the evidence

Autor:	Aminah Khan, Susan M. Bowyer, Matthew P. Galloway, Nash N. Boutros, Samiran Ghosh
Rok vydání:	2014
Předmět:	medicine.medical_specialty medicine.medical_treatment Nonbenzodiazepine Antiepileptic drug Controlled studies Electroencephalography Eeg data medicine Humans Psychiatry medicine.diagnostic_test Patient Selection Panic disorder Panic medicine.disease Databases Bibliographic Psychiatry and Mental health Treatment Outcome Anticonvulsant Epilepsy Temporal Lobe Practice Guidelines as Topic Panic Disorder Anticonvulsants medicine.symptom Psychology Publication Bias
Zdroj:	International Journal of Psychiatry in Clinical Practice. 18:2-10
ISSN:	1471-1788 1365-1501
DOI:	10.3109/13651501.2013.873053
Popis:	Currently, there are no guidelines for when to use an antiepileptic drug (AED) in nonepileptic panic disorder (PD) patients. We conducted this review to ascertain what guidance available literature can provide as to when to consider AEDs for PD patients.The primary data sources were PubMed and Google-Scholars. Search was limited to "English" and "Humans". Only papers addressing use of nonbenzodiazepine AEDs in PD were included. Data regarding study subjects, the AED utilized, and clinical responses were collected. EEG data were used to classify reports of patients with abnormal versus those with normal and/or no EEG work-up.Ten reports were identified for use of AEDs in PD patients with abnormal EEGs with a total of 20 patients (17 responders). None of the 10 reports were controlled studies. Eighteen reports were identified for use of AEDs in panic patients with either normal EEGs or unselected groups (no EEG work-up). Out of the 18 reports, three were controlled studies. Included in the 18 studies were 253 patients (137 responders).We preliminary concluded that EEG work-up could be useful in guiding the treatment in PD as an abnormal EEG may be indicative of a higher likelihood of a positive response to an AED.
Databáze:	OpenAIRE
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