Insight into stem cell regulation from sub-lethally irradiated worms
| Autor: | Luigi Tana, Claudio Ghezzani, Paola Iacopetti, Gregory Gimenez, Eric Ghigo, Alessandra Salvetti, Lucia Cassella, Leonardo Rossi |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cellular differentiation Messenger Models Biological 03 medical and health sciences 0302 clinical medicine Models RNA interference Niche Genetics Control network Gene silencing Animals Regeneration Developmental RNA Messenger Gene Planarian biology Gene Expression Profiling Stem Cells X-Rays Gene Expression Regulation Developmental Neoblast RNAi Cell Differentiation Planarians General Medicine Biological biology.organism_classification Cell biology 030104 developmental biology Gene Expression Regulation RNA Repopulation Stem cell 030217 neurology & neurosurgery |
| Zdroj: | Gene. 662 |
| ISSN: | 1879-0038 |
| Popis: | Despite the significant advances in the comprehension of stem cell control network, the nature of extrinsic signals regulating their dynamic remains to be understood. In this paper, we take advantage of the stem cell repopulation process that follows low-dose X-ray treatment in planarians to identify genes, preferentially enriched in differentiated cells, whose expression is activated during the process. Genetic silencing of some of them impaired the stem cell repopulation, suggesting a tight extrinsic control of stem cell activity. |
| Databáze: | OpenAIRE |
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