The association of incidentally detected heart valve calcification with future cardiovascular events
| Autor: | Gondrie, M.J.A., van der Graaf, Y., Jacobs, P.C., Oen, A.L., Mali, W.P.T.M., van Kuijk, C. |
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| Přispěvatelé: | Beeldvorming, RS: CARIM School for Cardiovascular Diseases, Radiology and nuclear medicine, Other Research |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Thorax
Adult Male medicine.medical_specialty Mitral annular calcification Cohort Studies Computed Tomography Internal medicine medicine Image Processing Computer-Assisted Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Neuroradiology Mitral valve calcification Aged Heart valves Aged 80 and over medicine.diagnostic_test business.industry Calcinosis Interventional radiology General Medicine Survival analysis Middle Aged Prognosis Heart valve calcification Cardiovascular diseases Radiology Nuclear Medicine and imaging Aortic Valve cardiovascular system Cardiology Mitral Valve Female Radiography Thoracic Radiology Aortic valve calcification business Tomography X-Ray Computed Valve disease |
| Zdroj: | European Radiology European Radiology, 21(5), 963-973. Springer, Cham European Radiology, 21(5), 963-973. Springer Verlag Gondrie, M J A, van der Graaf, Y, Jacobs, P C, Oen, A L, Mali, W P T M & van Kuijk, C 2011, ' The association of incidentally detected heart valve calcification with future cardiovascular events ', European Radiology, vol. 21, no. 5, pp. 963-973 . https://doi.org/10.1007/s00330-010-1995-0 |
| ISSN: | 1432-1084 0938-7994 |
| Popis: | Objectives This study aims to investigate the prognostic value of incidental aortic valve calcification (AVC), mitral valve calcification (MVC) and mitral annular calcification (MAC) for cardiovascular events and non-rheumatic valve disease in particular on routine diagnostic chest CT. Methods The study followed a case-cohort design. 10410 patients undergoing chest CT were followed for a median period of 17 months. Patients referred for cardiovascular disease were excluded. A random sample of 1285 subjects and the subjects who experienced an endpoint were graded for valve calcification by three reviewers. Cox-proportional hazard analysis was performed to evaluate the prognostic value. Results 515 cardiovascular events were ascertained. Compared with patients with no valve calcification, patients with severe AVC, MVC or MAC had respectively 2.03 (1.48–2.78), 2.08 (1.04–4.19) and 1.53 (1.13–2.08) increased risks of experiencing an event during follow-up. For valve endpoints the hazard ratios were respectively 14.57 (5.19–40.53), 8.78 (2.33–33.13) and 2.43 (1.18–4.98). Conclusion Incidental heart valve calcification, detected on routine chest CT is an independent predictor of future cardiovascular events. The study emphasises how incidental imaging findings can contribute to clinical care. It is a step in the process of composing an evidence-based approach in the reporting of incidental subclinical findings. |
| Databáze: | OpenAIRE |
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