Serum concentration and safety of intravenous drip versus subcutaneous administration of carboplatin in dogs
| Autor: | Masataka Iwano, Kensuke Orito, Hideki Kayanuma, Takuya Maruo, Shinpei Kawarai, Kohei Sadahiro |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
route of injection
medicine.medical_specialty endocrine system diseases Neutropenia Cat Diseases Gastroenterology Carboplatin chemistry.chemical_compound Dogs Internal medicine Internal Medicine medicine Animals Blood test Platelet Dog Diseases Infusions Intravenous Adverse effect neoplasms subcutaneous administration Cross-Over Studies CATS Full Paper General Veterinary medicine.diagnostic_test business.industry musculoskeletal system medicine.disease Crossover study female genital diseases and pregnancy complications veterinary medicine chemistry dog Toxicity Cats business therapeutics |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.20-0653 |
| Popis: | Carboplatin is used to treat certain cancers in dogs and cats and is routinely administered via intravenous drip (IVD). Subcutaneous (SC) administration has also been described. However, the toxicity, serum concentrations, and area under blood concentration-time curves (AUCs) of SC carboplatin are unknown. This study aimed to compare serum carboplatin concentrations in dogs after SC and IVD and to monitor any adverse events. In this crossover study, five dogs received SC or IV carboplatin (300 mg/m2). After a minimum of 3 weeks, each dog received the other treatment. No gross skin toxicity or abnormal clinical signs were observed in any of the dogs. Blood test abnormalities were detected in most dogs. Decreased neutrophil and platelet counts, and increased C-reactive protein (CRP) levels were found. There was no significant difference in the neutropenia, thrombocytopenia, and CRP scores between the groups. Systemic toxicities of SC carboplatin were comparable to those of IVD carboplatin. The time to maximum carboplatin concentration after SC was longer than that after IVD (P |
| Databáze: | OpenAIRE |
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