Early Intervention of Cold-Water Swimming on Functional Recovery and Spinal Pain Modulation Following Brachial Plexus Avulsion in Rats
| Autor: | Yueh-Ling Hsieh, Nian-Pu Yang, Shih-Fong Chen, Yu-Lin Lu, Chen-Chia Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
endocrine system functional recovery pain modulation QH301-705.5 Catalysis Inorganic Chemistry Rats Sprague-Dawley brachial plexus avulsion Animals Brachial Plexus Physical and Theoretical Chemistry Biology (General) Brachial Plexus Neuropathies Molecular Biology QD1-999 Spectroscopy Swimming urogenital system Organic Chemistry cold-water swimming Water General Medicine Recovery of Function Computer Science Applications Rats Cold Temperature Disease Models Animal Chemistry Spinal Injuries Neuralgia hormones hormone substitutes and hormone antagonists |
| Zdroj: | International Journal of Molecular Sciences, Vol 23, Iss 1178, p 1178 (2022) International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1178 |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Brachial plexus avulsion (BPA) causes peripheral nerve injury complications with motor and sensory dysfunction of the upper limb. Growing evidence has shown an active role played by cold-water swimming (CWS) in alleviating peripheral neuropathic pain and functional recovery. This study examined whether CWS could promote functional recovery and pain modulation through the reduction of neuroinflammation and microglial overactivation in dorsal horn neurons at the early-stage of BPA. After BPA surgery was performed on rats, they were assigned to CWS or sham training for 5 min twice a day for two weeks. Functional behavioral responses were tested before and after BPA surgery, and each week during training. Results after the two-week training program showed significant improvements in BPA-induced motor and sensory loss (p < 0.05), lower inflammatory cell infiltration, and vacuole formation in injured nerves among the BPA–CWS group. Moreover, BPA significantly increased the expression of SP and IBA1 in dorsal horn neurons (p < 0.05), whereas CWS prevented their overexpression in the BPA–CWS group. The present findings evidenced beneficial rehabilitative effects of CWS on functional recovery and pain modulation at early-stage BPA. The beneficial effects are partially related to inflammatory suppression and spinal modulation. The synergistic role of CWS combined with other management approaches merits further investigation. |
| Databáze: | OpenAIRE |
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