Tolerability and utility of mangafodipir trisodium injection (MnDPDP) at the dose of 5 mumol/kg body weight in detecting focal liver tumors: results of a phase III trial using an infusion technique
| Autor: | Marit Lambrechts, Patrick Chevallier, Jacques Drouillard, Jean Noël Bruneton, Paul Gordon, Robin Lecesne, Charles Raffaelli, Bernard Padovani |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Carcinoma Hepatocellular Contrast Media Computed tomography Body weight Mangafodipir medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Adverse effect Infusions Intravenous Edetic Acid Manganese medicine.diagnostic_test business.industry Liver Neoplasms Mangafodipir trisodium Magnetic resonance imaging General Medicine Middle Aged medicine.disease Tolerability Pyridoxal Phosphate Female Radiology business Nuclear medicine Tomography X-Ray Computed medicine.drug |
| Zdroj: | European journal of radiology. 23(3) |
| ISSN: | 0720-048X |
| Popis: | Purpose : To evaluate the tolerability of mangafodipir trisodium (MnDPDP) and its utility for enhancing the ability of magnetic resonance (MR) imaging to detect focal hepatic lesions compared with non-enhanced MR and contrast-enhanced computed tomography (CT). Materials and methods : 119 patients with focal hepatic lesions were examined by MR and by contrast-enhanced CT. MR was performed before and after the infusion of 5 μmol/kg MnDPDP, at a concentration of 10 μmol/ml. Histologic confirmation was obtained in 79 patients. Results : There were no severe adverse events. Five patients reported mild adverse events related to the infusion. MnDPDP-enhanced SE T1 and GE T1 sequences revealed more focal lesions than the same sequences before contrast infusion in, respectively 22.6 and 36.1% of the cases, and fewer focal lesions in, respectively 5.9 and 1.7% of the cases. Contrast-enhanced MR demonstrated more focal lesions than the SE T2 sequence in 29.4% of cases and fewer lesions in 5.9% of cases. MnDPDP-enhanced MR revealed more nodules than CT in 31.1% of cases and fewer nodules in 13.4% of cases. The additional information provided by MnDPDP enhancement led to modification of management for 12 patients (10.1%). Conclusion : MnDPDP is a well-tolerated contrast agent allowing better MR detection of focal hepatic lesions than non-enhanced MR or contrast-enhanced CT. |
| Databáze: | OpenAIRE |
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