Comparative evaluation of antidiabetic potential of partially purified bioactive fractions from four medicinal plants in alloxan-induced diabetic rats
| Autor: | Santosh B Dighe, Pandurang Dighe, Sunil A. Nirmal, B K Salalkar, Twinkle S. Bansode |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Trigonella biology Glycogen Traditional medicine 030231 tropical medicine Flavonoid Saponin General Medicine 030108 mycology & parasitology biology.organism_classification Terminalia chebula 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Salvadora persica Alloxan Medicinal plants |
| Zdroj: | Ayu. 38(3-4) |
| ISSN: | 0974-8520 |
| Popis: | Background: Syzygium cumini, Terminalia chebula, Trigonella foenum graecum and Salvadora persica are medicinally important plants well known for their pharmacological activities. Aim: The aim of this study is to compare the antidiabetic potential of partially purified bioactive fractions isolated from four targeted medicinal plants in diabetic rats. Methods: Alloxan was administered (125 mg/kg, IP) in albino Wistar rats to produce diabetes. The partially purified bioactive fractions, namely S. cumini tannin fraction (ScTF), T. foenum graecum (Fenugreek) saponin fraction (FgSF), T. chebula flavonoid fraction (TcFF) and S. persica flavonoid fraction (SpFF), were administered to diabetic rats with the dose of 100 mg/kg, per oral (PO) and the effect of the fractions on body weight, liver glycogen and serum glucose were studied up to 15 days. Results: The results have indicated that diabetic rats treated with fractions showed a statistically significant (P |
| Databáze: | OpenAIRE |
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