Prediction of eye and skin color in diverse populations using seven SNPs
| Autor: | Damir Marjanović, Zoran M. Budimlija, Mechthild Prinz, Elisa Wurmbach, Lejla Kovacevic, Adele A. Mitchell, Andreas Jenny, Olga Spichenok, Theresa Caragine |
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| Rok vydání: | 2011 |
| Předmět: |
Molecular Sequence Data
Population Skin Pigmentation Single-nucleotide polymorphism Biology Polymerase Chain Reaction Polymorphism Single Nucleotide Pathology and Forensic Medicine Dna genetics Polymorphism (computer science) Sequence Homology Nucleic Acid Genetics Eye color Animals Humans Base sequence education education.field_of_study Base Sequence Eye Color DNA Genetics Population Pigmentation Skin color SNPs Identification of human remains DNA phenotyping |
| Zdroj: | Forensic Science International: Genetics. 5:472-478 |
| ISSN: | 1872-4973 |
| DOI: | 10.1016/j.fsigen.2010.10.005 |
| Popis: | An essential component in identifying human remains is the documentation of the decedent's visible characteristics, such as eye, hair and skin color. However, if a decedent is decomposed or only skeletal remains are found, this critical, visibly identifying information is lost. It would be beneficial to use genetic information to reveal these visible characteristics. In this study, seven single nucleotide polymorphisms (SNPs), located in and nearby genes known for their important role in pigmentation, were validated on 554 samples, donated from non-related individuals of various populations. Six SNPs were used in predicting the eye color of an individual, and all seven were used to describe the skin coloration. The outcome revealed that these markers can be applied to all populations with very low error rates. However, the call-rate to determine the skin coloration varied between populations, demonstrating its complexity. Overall, these results prove the importance of these seven SNPs for potential forensic tests. (C) 2010 Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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