Protective effects of a chalcone derivative against Aβ-induced oxidative stress and neuronal damage
| Autor: | Young Hwa Na, Ho-Geun Yoon, Yoo-Hyun Lee, Mi Jeong Kim, Ji Eun Kwak |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Programmed cell death Chalcone Amyloid Cell Survival medicine.disease_cause Biochemistry PC12 Cells chemistry.chemical_compound Mice In vivo Neuronal damage Memory medicine Animals Molecular Biology Chalcone derivative Neurons Mice Inbred ICR Amyloid beta-Peptides Cell Death Body Weight General Medicine Free Radical Scavengers In vitro Peptide Fragments Rats Oxidative Stress Neuroprotective Agents chemistry Oxidative stress |
| Zdroj: | BMB reports. 44(11) |
| ISSN: | 1976-670X |
| Popis: | Amyloid Β-peptide (AΒ-peptide)-induced oxidative stress is thought to be a critical component of the pathophysiology of Alzheimer's disease (AD). New chalcone derivatives, the Chana series, were recently synthesized from the retrochalcones of licorice. In this study, we investigated the protective effects of the Chana series against neurodegenerative changes in vitro and in vivo. Among the Chana series, Chana 30 showed the highest free radical scavenging activity (90.7%) in the 1,1-diphenyl-2- picrylhydrazyl assay. Chana 30 also protected against AΒ-induced neural cell injury in vitro. Furthermore, Chana 30 reduced the learning and memory deficits of AΒ(1-42)-peptide injected mice. Taken together, these results suggest that Chana 30 may be a promising candidate as a potent therapeutic agent against neurodegenerative diseases. [BMB reports 2011; 44(11): 730-734]. |
| Databáze: | OpenAIRE |
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