Associations between ERα/β gene polymorphisms and osteoporosis susceptibility and bone mineral density in postmenopausal women: a systematic review and meta-analysis
| Autor: | Qiang Wang, Youjia Xu, Heping Zhu, Jun Zong, Jiannong Jiang, Liang Zhang, Leiyan Zhang, Tieliang Ma |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Genotype Bone density Endocrinology Diabetes and Metabolism Osteoporosis Estrogen receptor 030209 endocrinology & metabolism lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences Postmenopausal osteoporosis 0302 clinical medicine Bone Density Internal medicine medicine Estrogen Receptor beta Humans Genetic Predisposition to Disease Osteoporosis Postmenopausal Estrogen receptor beta lcsh:RC648-665 Polymorphism Genetic business.industry Estrogen Receptor alpha Gene polymorphism General Medicine medicine.disease Meta-analysis 030104 developmental biology Endocrinology Female business XX Genotype Estrogen receptor alpha Research Article |
| Zdroj: | BMC Endocrine Disorders BMC Endocrine Disorders, Vol 18, Iss 1, Pp 1-16 (2018) |
| ISSN: | 1472-6823 |
| DOI: | 10.1186/s12902-018-0230-x |
| Popis: | Background Many studies have reported associations between estrogen receptor (ER) gene polymorphisms and postmenopausal osteoporosis (PMOP) risk and bone mineral density (BMD), but the results are controversial. The aim of the present meta-analysis is to verify the association between ERα and ERβ gene polymorphisms and osteoporosis susceptibility and BMD in postmenopausal women. Methods PubMed, EMBASE, Web of Science, the Cochrane Library and China WeiPu Library were searched. OR and WMD with 95% CI were calculated to assess the association. Results Overall, no significant association was observed between ERα XbaI, ERα PvuII and PMOP susceptibility in either overall, Caucasian or Asian populations. ERα G2014A was significantly associated with a decreased risk of PMOP in Caucasian populations. There was a significant association between ERβ RsaI and PMOP risk in both overall and Asian populations. Caucasian PMOP women with ERα XbaI XX and Xx genotypes had a higher LS Z value than women with xx genotype. ERα XbaI XX genotype was associated with increased FN BMD in overall and Caucasian populations, an increased FN Z value in Asians, and a decreased FN Z value in Caucasians. There was also a significant association between ERα XbaI Xx genotype and an increased FN Z value in either Asians or Caucasians. ERα PvuII PP genotype was associated with a low LS Z value in Caucasians and a low FN BMD and Z value in Asians. Pp genotype in PMOP women was significantly correlated with low LS BMD in overall populations, a low FN Z value in either overall, Caucasian or Asian populations. Conclusion Each ERα and ERβ gene polymorphism might have different impact on PMOP risk and BMD in various ethnicities. |
| Databáze: | OpenAIRE |
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