Amyloid peptide toxicity and microtubule-stabilizing drugs
| Autor: | Gunda I. Georg, Emily A. Reiff, Yingxue Chen, Mary L. Michaelis, Sarah Hill, Antonie Rice, Kenneth L. Audus |
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| Rok vydání: | 2001 |
| Předmět: |
Paclitaxel
Peptide macromolecular substances Pharmacology Biology Blood–brain barrier Neuroprotection Microtubules Cellular and Molecular Neuroscience Microtubule Slow progression Alzheimer Disease medicine Animals Cytoskeleton Cells Cultured chemistry.chemical_classification Neurons Amyloid beta-Peptides Cell Death Neurodegeneration General Medicine medicine.disease Rats medicine.anatomical_structure Neuroprotective Agents chemistry Blood-Brain Barrier Toxicity Neuroscience |
| Zdroj: | Journal of molecular neuroscience : MN. 19(1-2) |
| ISSN: | 0895-8696 |
| Popis: | Based on microtubule (MT) disruption observed in primary neurons exposed to fibrillar amyloid peptides (A beta), we tested the potential protective effect of MT-stabilizing drugs such as Taxol against A beta-induced disruption of the cytoskeleton. Although Taxol was strongly protective, the fact that it does not cross the blood brain barrier (BBB) led us to synthesize and test other agents with MT-stabilizing properties and possible penetration into the brain. Our studies have thus far demonstrated that several MT-stabilizing agents, including some with structures quite different from that of Taxol, showed significant protective effects. However, not all agents that promoted MT-assembly were protective, suggesting additional mechanisms are involved in the actions of the drugs. A small number of neuroprotective compounds appear to have potential to enter the brain and thus might be tested to see if they slow progression of neurodegeneration in an appropriate animal model of Alzheimer's disease. |
| Databáze: | OpenAIRE |
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