Dynamics of the human skin mediator lipidome in response to dietary omega-3 fatty acid supplementation
| Autor: | Anna Nicolaou, Francesco Del Carratore, Suzanne M. Pilkington, Rachel E.B. Watson, Paula Urquhart, Rainer Breitling, Sharon Murphy, Lesley E. Rhodes, Anggit L. Sunarwidhi, Magdalena Kiezel-Tsugunova, Alexandra C. Kendall |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male 0301 basic medicine eicosapentaenoic acid Adolescent Nutritional Supplementation Lydia Becker Institute CD8-Positive T-Lymphocytes Biochemistry Young Adult 03 medical and health sciences 0302 clinical medicine ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation Fatty Acids Omega-3 Lipidomics Genetics Humans Food science Molecular Biology mass spectrometry Skin chemistry.chemical_classification integumentary system Mass spectrometry Research Fatty acid Middle Aged Lipidome docosahexaenoic acid Fish oil Eicosapentaenoic acid 030104 developmental biology chemistry Docosahexaenoic acid inflammation Dietary Supplements lipidomics Female lipids (amino acids peptides and proteins) 030217 neurology & neurosurgery Biotechnology Polyunsaturated fatty acid |
| Zdroj: | Kendall, A, Pilkington, S, Murphy, S, Del Carratore, F, Sunarwidhi, A L, Kiezel-Tsugunova, M, Urquhart, P, Watson, R, Breitling, R, Rhodes, L & Nicolaou, A 2019, ' Dynamics of the human skin mediator lipidome in response to dietary omega-3 fatty acid supplementation ', The FASEB journal : official publication of the Federation of American Societies for Experimental Biology . https://doi.org/10.1096/fj.201901501R Kendall, A C, Pilkington, S M, Murphy, S A, Del Carratore, F, Sunarwidhi, A L, Kiezel-Tsugunova, M, Urquhart, P, Watson, R E B, Breitling, R, Rhodes, L E & Nicolaou, A 2019, ' Dynamics of the human skin mediator lipidome in response to dietary ω-3 fatty acid supplementation ', The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 33, no. 11, pp. 13014-13027 . https://doi.org/10.1096/fj.201901501R PDF The FASEB Journal |
| Popis: | Nutritional supplementation with fish oil or ω-3 (n-3) polyunsaturated fatty acids (PUFAs) has potential benefits for skin inflammation. Although the differential metabolism of the main n-3PUFA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) could lead to distinct activities, there are no clinical studies comparing their relative efficacy in human skin. Following a 10-wk oral supplementation of healthy volunteers and using mass spectrometry-based lipidomics, we found that n-3PUFA mainly affected the epidermal mediator lipidome. EPA was more efficient than DHA in reducing production of arachidonic acid–derived lipids, and both n-3PUFA lowered N-acyl ethanolamines. In UV radiation–challenged skin (3 times the minimum erythemal dose), EPA attenuated the production of proinflammatory lipids, whereas DHA abrogated the migration of Langerhans cells, as assessed by immunohistochemistry. Interestingly, n-3PUFA increased the infiltration of CD4+ and CD8+ T cells but did not alter the erythemal response, either the sunburn threshold or the resolution of erythema, as assessed by spectrophotometric hemoglobin index readings. As EPA and DHA differentially impact cutaneous inflammation through changes in the network of epidermal lipids and dendritic and infiltrating immune cells, they should be considered separately when designing interventions for cutaneous disease.—Kendall, A. C., Pilkington, S. M., Murphy, S. A., Del Carratore, F., Sunarwidhi, A. L., Kiezel-Tsugunova, M., Urquhart, P., Watson, R. E. B., Breitling, R., Rhodes, L. E., Nicolaou, A. Dynamics of the human skin mediator lipidome in response to dietary ω-3 fatty acid supplementation. |
| Databáze: | OpenAIRE |
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