Rare Pelvic Malignant Tumors in Adults: Treatment Features and Clinical Outcome in Nonmetastatic Disease (Single Institution Experience)
| Autor: | Xenia Bacinschi, Georgia-Luiza Serbanescu, Rodica Anghel, Inga Botnariuc, Silvia Mihaela Ilie, Oana Trifanescu, Cristina Orlov, Fabiana Curea |
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| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Male Cancer Research Pediatrics medicine.medical_specialty business.industry General Medicine Disease Middle Aged Outcome (game theory) Treatment Outcome Oncology Multimodal treatment Medicine Humans Radiology Nuclear Medicine and imaging Female Single institution business Pelvic Neoplasms |
| Zdroj: | Cancer biotherapyradiopharmaceuticals. 34(1) |
| ISSN: | 1557-8852 |
| Popis: | Nearly 200 cancers repertories are rare, and more than 20% are pelvic neoplasia. Diagnosis and treatment are challenging, even in reference centers, and survival is influenced by the aggressiveness of certain histologies and absence of a standard of care.The authors report the results of a retrospective analysis of patients that attended the Institute of Oncology, Bucharest, between 2004 and 2015, for nonmetastatic pelvic malignant tumor treatment and follow-up. The outcomes are compared between the rare and common histology groups.Of the 60 cases analyzed, 17 patients (28.33%) bore a rare tumor, 33 (55%) were women, and the median age was 59 years. The majority was concerned by bladder (41.66%, 25 patients) and cervix (23.33%, 14 patients) neoplasms. For a median follow-up of 27.5 months, relapse was registered in 27 patients (45%), of whom 9 (33.33%) were from the rare group (53% of this subpopulation). The highest relapse rates were recorded in patients with rare bladder tumors (66.7%, 4 patients) compared with 42.1% (8 patients) in the common group (p = 0.294) and in prostate localization (66.7%, 2 patients) compared with 16.7% (1 patient) (p = 0.134). Estimated median relapse-free survival (RFS) was 60, 12 months in the rare group and 67 months for common tumors.In nonmetastatic rare pelvic tumor patients, the outcome was found to be poorer than in those concerned by common histologies stratified by organ. A higher rate of relapse and the lowest median RFS were observed in bladder and prostatic cancers. |
| Databáze: | OpenAIRE |
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